Poor prognosis in human papillomavirus-positive oropharyngeal squamous cell carcinomas that overexpress hypoxia inducible factor-1α.
Justin Egidius SwartzAjit Joe PothenPauline Maria Wilhelmina van KempenInge StegemanFleurieke Karlijn FormsmaEllen Maria Van CannStefan Martin WillemsWilko GrolmanPublished in: Head & neck (2016)
HIF-1α overexpression is associated with worse OS and characterized a subgroup of patients with HPV-positive oropharyngeal SCC with poor prognosis. Possibly, patients with HIF-1α overexpressing HPV-positive tumors should not be eligible for treatment dose deescalation. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1338-1346, 2016.