Cyclocreatine Suppresses Creatine Metabolism and Impairs Prostate Cancer Progression.

Rachana PatelCatriona A FordLisa RodgersLinda K RushworthJanis FlemingErnest MuiTong ZhangDavid G WatsonVictoria LynchGillian MackayDavid Sumpton Owen James Sansom Johan Vande Voorde Hing Y Leung

Published in: Cancer research (2022)

Enhanced creatine uptake drives prostate cancer progression and confers a metabolic vulnerability to treatment with the creatine analog cyclocreatine.

Keyphrases

prostate cancer
radical prostatectomy
climate change
signaling pathway