A pathogenic variant in RAB32 causes autosomal dominant Parkinson's disease and activates LRRK2 kinase.

Emil Karl Gustavsson Jordan Follett Joanne Trinh Sandeep Kumar Barodia Raquel Real Zhiyong Liu Melissa Grant-Peters Jesse D Fox Silke Appel-Cresswell A Jon Stoessl Alex RajputAli H RajputRoland Auer Russel Tilney Marc Sturm Tobias B Haack Suzanne Lesage Christelle Tesson Alexis BriceCarles Vilariño-GüellMina Ryten Matthew S Goldberg Andrew B West Michele Tao-Ming Hu Huw R MorrisManu SharmaZiv Gan Or Bedia Samanci Pawel Lis Maria Teresa Periñán Rim Amouri Samia Ben SassiFaycel Hentatinull nullFrancesca Tonelli Dario R Alessi Matthew J Farrer

Published in: medRxiv : the preprint server for health sciences (2024)

National Institutes of Health, the Canada Excellence Research Chairs program, Aligning Science Across Parkinson's, the Michael J. Fox Foundation for Parkinson's Research, and the UK Medical Research Council.

Keyphrases

public health
healthcare
quality improvement
mental health
cross sectional
tyrosine kinase
protein kinase
risk assessment
social media