Dario R Alessi

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 63

Top Venues

Science advances

Science (New York, N.Y.)

medRxiv : the preprint server for health sciences

Nature neuroscience

University of Dundee

University of Birmingham (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Dundee Oct 01 1991

United Kingdom

Director of MRC Protein Phosphorylation and Ubiquitylation Unit :: School of Life Sciences

Education History

University of Birmingham

United Kingdom

PHD

University of Birmingham

United Kingdom

BSC :: School of Biochemistry

Publications

Carmelo Milioto, Mireia Carcolé, Ashling Giblin, Rachel Coneys, Olivia Attrebi, Mhoriam Ahmed, Samuel S Harris, Byung Il Lee, Mengke Yang, Robert A Ellingford, Raja S Nirujogi, Daniel Biggs, Sally Salomonsson, Matteo Zanovello, Paula de Oliveira, Eszter Katona, Idoia Glaria, Alla Mikheenko, Bethany Geary, Evan Udine, Deniz Vaizoglu, Sharifah Anoar, Khrisha Jotangiya, Gerard Crowley, Demelza M Smeeth, Mirjam L Adams, Teresa Niccoli, Rosa Rademakers, Marka van Blitterswijk, Anny Devoy, Soyon Hong, Linda Partridge, Alyssa N Coyne, Pietro Fratta, Dario R Alessi, Benjamin Davies, Marc Aurel Busche, Linda Greensmith, Elizabeth M C Fisher, Adrian M Isaacs
PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons. Nature neuroscience (2024)
Carmelo Milioto, Mireia Carcolé, Ashling Giblin, Rachel Coneys, Olivia Attrebi, Mhoriam Ahmed, Samuel S Harris, Byung Il Lee, Mengke Yang, Robert A Ellingford, Raja S Nirujogi, Daniel Biggs, Sally Salomonsson, Matteo Zanovello, Paula de Oliveira, Eszter Katona, Idoia Glaria, Alla Mikheenko, Bethany Geary, Evan Udine, Deniz Vaizoglu, Sharifah Anoar, Khrisha Jotangiya, Gerard Crowley, Demelza M Smeeth, Mirjam L Adams, Teresa Niccoli, Rosa Rademakers, Marka van Blitterswijk, Anny Devoy, Soyon Hong, Linda Partridge, Alyssa N Coyne, Pietro Fratta, Dario R Alessi, Benjamin Davies, Marc Aurel Busche, Linda Greensmith, Elizabeth M C Fisher, Adrian M Isaacs
PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons. Nature neuroscience (2024)
Shahzad S Khan, Ebsy Jaimon, Yu-En Lin, Jonas M Nikoloff, Francesca Tonelli, Dario R Alessi, Suzanne R Pfeffer
Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America 121 (32) (2024)
Emil Karl Gustavsson, Jordan Follett, Joanne Trinh, Sandeep Kumar Barodia, Raquel Real, Zhiyong Liu, Melissa Grant-Peters, Jesse D Fox, Silke Appel-Cresswell, A Jon Stoessl, Alex Rajput, Ali H Rajput, Roland Auer, Russel Tilney, Marc Sturm, Tobias B Haack, Suzanne Lesage, Christelle Tesson, Alexis Brice, Carles Vilariño-Güell, Mina Ryten, Matthew S Goldberg, Andrew B West, Michele Tao-Ming Hu, Huw R Morris, Manu Sharma, Ziv Gan Or, Bedia Samanci, Pawel Lis, Maria Teresa Periñán, Rim Amouri, Samia Ben Sassi, Faycel Hentati, null null, Francesca Tonelli, Dario R Alessi, Matthew J Farrer
A pathogenic variant in RAB32 causes autosomal dominant Parkinson's disease and activates LRRK2 kinase . medRxiv : the preprint server for health sciences (2024)
Carmelo Milioto, Mireia Carcolé, Ashling Giblin, Rachel Coneys, Olivia Attrebi, Mhoriam Ahmed, Samuel S Harris, Byung Il Lee, Mengke Yang, Robert A Ellingford, Raja S Nirujogi, Daniel Biggs, Sally Salomonsson, Matteo Zanovello, Paula de Oliveira, Eszter Katona, Idoia Glaria, Alla Mikheenko, Bethany Geary, Evan Udine, Deniz Vaizoglu, Sharifah Anoar, Khrisha Jotangiya, Gerard Crowley, Demelza M Smeeth, Mirjam L Adams, Teresa Niccoli, Rosa Rademakers, Marka van Blitterswijk, Anny Devoy, Soyon Hong, Linda Partridge, Alyssa N Coyne, Pietro Fratta, Dario R Alessi, Benjamin Davies, Marc Aurel Busche, Linda Greensmith, Elizabeth M C Fisher, Adrian M Isaacs
PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons. Nature neuroscience 27 (4) (2024)
Shahzad S Khan, Ebsy Jaimon, Yu-En Lin, Jonas M Nikoloff, Francesca Tonelli, Dario R Alessi, Suzanne R Pfeffer
Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America 121 (32) (2024)
Emil Karl Gustavsson, Jordan Follett, Joanne Trinh, Sandeep Kumar Barodia, Raquel Real, Zhiyong Liu, Melissa Grant-Peters, Jesse D Fox, Silke Appel-Cresswell, A Jon Stoessl, Alex Rajput, Ali H Rajput, Roland Auer, Russel Tilney, Marc Sturm, Tobias B Haack, Suzanne Lesage, Christelle Tesson, Alexis Brice, Carles Vilariño-Güell, Mina Ryten, Matthew S Goldberg, Andrew B West, Michele Tao-Ming Hu, Huw R Morris, Manu Sharma, Ziv Gan Or, Bedia Samanci, Pawel Lis, Maria Teresa Periñán, Rim Amouri, Samia Ben Sassi, Faycel Hentati, null null, Francesca Tonelli, Dario R Alessi, Matthew J Farrer
A pathogenic variant in RAB32 causes autosomal dominant Parkinson's disease and activates LRRK2 kinase. medRxiv : the preprint server for health sciences (2024)
Emil Karl Gustavsson, Jordan Follett, Joanne Trinh, Sandeep Kumar Barodia, Raquel Real, Zhiyong Liu, Melissa Grant-Peters, Jesse D Fox, Silke Appel-Cresswell, A Jon Stoessl, Alex Rajput, Ali H Rajput, Roland Auer, Russel Tilney, Marc Sturm, Tobias B Haack, Suzanne Lesage, Christelle Tesson, Alexis Brice, Carles Vilariño-Güell, Mina Ryten, Matthew S Goldberg, Andrew B West, Michele Tao-Ming Hu, Huw R Morris, Manu Sharma, Ziv Gan Or, Bedia Samanci, Pawel Lis, Maria Teresa Periñán, Rim Amouri, Samia Ben Sassi, Faycel Hentati, null null, Francesca Tonelli, Dario R Alessi, Matthew J Farrer
A pathogenic variant in RAB32 causes autosomal dominant Parkinson's disease and activates LRRK2 kinase. medRxiv : the preprint server for health sciences (2024)
Carmelo Milioto, Mireia Carcolé, Ashling Giblin, Rachel Coneys, Olivia Attrebi, Mhoriam Ahmed, Samuel S Harris, Byung Il Lee, Mengke Yang, Robert A Ellingford, Raja S Nirujogi, Daniel Biggs, Sally Salomonsson, Matteo Zanovello, Paula de Oliveira, Eszter Katona, Idoia Glaria, Alla Mikheenko, Bethany Geary, Evan Udine, Deniz Vaizoglu, Sharifah Anoar, Khrisha Jotangiya, Gerard Crowley, Demelza M Smeeth, Mirjam L Adams, Teresa Niccoli, Rosa Rademakers, Marka van Blitterswijk, Anny Devoy, Soyon Hong, Linda Partridge, Alyssa N Coyne, Pietro Fratta, Dario R Alessi, Benjamin Davies, Marc Aurel Busche, Linda Greensmith, Elizabeth M C Fisher, Adrian M Isaacs
PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons. Nature neuroscience 27 (4) (2024)
Shahzad S Khan, Ebsy Jaimon, Yu-En Lin, Jonas M Nikoloff, Francesca Tonelli, Dario R Alessi, Suzanne R Pfeffer
Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America 121 (32) (2024)
Carmelo Milioto, Mireia Carcolé, Ashling Giblin, Rachel Coneys, Olivia Attrebi, Mhoriam Ahmed, Samuel S Harris, Byung Il Lee, Mengke Yang, Robert A Ellingford, Raja S Nirujogi, Daniel Biggs, Sally Salomonsson, Matteo Zanovello, Paula de Oliveira, Eszter Katona, Idoia Glaria, Alla Mikheenko, Bethany Geary, Evan Udine, Deniz Vaizoglu, Sharifah Anoar, Khrisha Jotangiya, Gerard Crowley, Demelza M Smeeth, Mirjam L Adams, Teresa Niccoli, Rosa Rademakers, Marka van Blitterswijk, Anny Devoy, Soyon Hong, Linda Partridge, Alyssa N Coyne, Pietro Fratta, Dario R Alessi, Benjamin Davies, Marc Aurel Busche, Linda Greensmith, Elizabeth M C Fisher, Adrian M Isaacs
PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons. Nature neuroscience (2024)
Shahzad S Khan, Ebsy Jaimon, Yu-En Lin, Jonas M Nikoloff, Francesca Tonelli, Dario R Alessi, Suzanne R Pfeffer
Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson's disease. bioRxiv : the preprint server for biology (2024)
Shahzad S Khan, Ebsy Jaimon, Yu-En Lin, Jonas M Nikoloff, Francesca Tonelli, Dario R Alessi, Suzanne R Pfeffer
Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America 121 (32) (2024)
Francesca Magrinelli, Christelle Tesson, Plamena R Angelova, Ainara Salazar-Villacorta, Jose A Rodriguez, Annarita Scardamaglia, Brian Hon-Yin Chung, Matthew Jaconelli, Barbara Vona, Noemí Esteras, Anna Ka-Yee Kwong, Thomas Courtin, Reza Maroofian, Shahryar Alavi, Raja S Nirujogi, Mariasavina Severino, Patrick A Lewis, Stephanie Efthymiou, Benjamin J O'Callaghan, Rebecca Buchert, Linda Sofan, Pawel Lis, Chloé Pinon, Guido J Breedveld, Martin Man Chun Chui, David P Murphy, Vanessa Pitz, Mary B Makarious, Marlene Cassar, Bassem A Hassan, Sana Iftikhar, Clarissa Rocca, Peter Bauer, Michele Tinazzi, Marina Svetel, Bedia Samanci, Hasmet A Hanagasi, Basar Bilgiç, Jose A Obeso, Mónica M Kurtis, Guillaume Cogan, Ayse Nazli Basak, Güneş Kiziltan, Tuğçe Gül, Gül Yalçın Çakmaklı, Bülent Elibol, Nina Barisic, Earny Wei-Sen Ng, Sze-Shing Fan, Tova Hershkovitz, Karin Weiss, Javeria Raza Alvi, Tipu Sultan, Issam Azmi Alkhawaja, Tawfiq Froukh, Hadeel Abdollah E Alrukban, Christine Fauth, Ulrich A Schatz, Thomas Zöggeler, Michael Zech, Karen L Stals, Vinod C Varghese, Sonia Gandhi, Cornelis Blauwendraat, John A Hardy, Suzanne Lesage, Vincenzo Bonifati, Tobias B Haack, Aida Maria Bertoli-Avella, Robert Steinfeld, Dario R Alessi, Hermann Steller, Alexis Brice, Andrey Y Abramov, Kailash P Bhatia, Henry Houlden
PSMF1 variants cause a phenotypic spectrum from early-onset Parkinson's disease to perinatal lethality by disrupting mitochondrial pathways. medRxiv : the preprint server for health sciences (2024)
Francesca Magrinelli, Christelle Tesson, Plamena R Angelova, Ainara Salazar-Villacorta, Jose A Rodriguez, Annarita Scardamaglia, Brian Hon-Yin Chung, Matthew Jaconelli, Barbara Vona, Noemí Esteras, Anna Ka-Yee Kwong, Thomas Courtin, Reza Maroofian, Shahryar Alavi, Raja S Nirujogi, Mariasavina Severino, Patrick A Lewis, Stephanie Efthymiou, Benjamin J O'Callaghan, Rebecca Buchert, Linda Sofan, Pawel Lis, Chloé Pinon, Guido J Breedveld, Martin Man Chun Chui, David P Murphy, Vanessa Pitz, Mary B Makarious, Marlene Cassar, Bassem A Hassan, Sana Iftikhar, Clarissa Rocca, Peter Bauer, Michele Tinazzi, Marina Svetel, Bedia Samanci, Hasmet A Hanagasi, Basar Bilgiç, Jose A Obeso, Mónica M Kurtis, Guillaume Cogan, Ayse Nazli Basak, Güneş Kiziltan, Tuğçe Gül, Gül Yalçın Çakmaklı, Bülent Elibol, Nina Barisic, Earny Wei-Sen Ng, Sze-Shing Fan, Tova Hershkovitz, Karin Weiss, Javeria Raza Alvi, Tipu Sultan, Issam Azmi Alkhawaja, Tawfiq Froukh, Hadeel Abdollah E Alrukban, Christine Fauth, Ulrich A Schatz, Thomas Zöggeler, Michael Zech, Karen L Stals, Vinod C Varghese, Sonia Gandhi, Cornelis Blauwendraat, John A Hardy, Suzanne Lesage, Vincenzo Bonifati, Tobias B Haack, Aida Maria Bertoli-Avella, Robert Steinfeld, Dario R Alessi, Hermann Steller, Alexis Brice, Andrey Y Abramov, Kailash P Bhatia, Henry Houlden
PSMF1 variants cause a phenotypic spectrum from early-onset Parkinson's disease to perinatal lethality by disrupting mitochondrial pathways. medRxiv : the preprint server for health sciences (2024)
Carmelo Milioto, Mireia Carcolé, Ashling Giblin, Rachel Coneys, Olivia Attrebi, Mhoriam Ahmed, Samuel S Harris, Byung Il Lee, Mengke Yang, Robert A Ellingford, Raja S Nirujogi, Daniel Biggs, Sally Salomonsson, Matteo Zanovello, Paula de Oliveira, Eszter Katona, Idoia Glaria, Alla Mikheenko, Bethany Geary, Evan Udine, Deniz Vaizoglu, Sharifah Anoar, Khrisha Jotangiya, Gerard Crowley, Demelza M Smeeth, Mirjam L Adams, Teresa Niccoli, Rosa Rademakers, Marka van Blitterswijk, Anny Devoy, Soyon Hong, Linda Partridge, Alyssa N Coyne, Pietro Fratta, Dario R Alessi, Benjamin Davies, Marc Aurel Busche, Linda Greensmith, Elizabeth M C Fisher, Adrian M Isaacs
PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons. Nature neuroscience (2024)
Emil Karl Gustavsson, Jordan Follett, Joanne Trinh, Sandeep Kumar Barodia, Raquel Real, Zhiyong Liu, Melissa Grant-Peters, Jesse D Fox, Silke Appel-Cresswell, A Jon Stoessl, Alex Rajput, Ali H Rajput, Roland Auer, Russel Tilney, Marc Sturm, Tobias B Haack, Suzanne Lesage, Christelle Tesson, Alexis Brice, Carles Vilariño-Güell, Mina Ryten, Matthew S Goldberg, Andrew B West, Michele Tao-Ming Hu, Huw R Morris, Manu Sharma, Ziv Gan Or, Bedia Samanci, Pawel Lis, Maria Teresa Periñán, Rim Amouri, Samia Ben Sassi, Faycel Hentati, null null, Francesca Tonelli, Dario R Alessi, Matthew J Farrer
A pathogenic variant in RAB32 causes autosomal dominant Parkinson's disease and activates LRRK2 kinase. medRxiv : the preprint server for health sciences (2024)
Francesca Magrinelli, Christelle Tesson, Plamena R Angelova, Ainara Salazar-Villacorta, Jose A Rodriguez, Annarita Scardamaglia, Brian Hon-Yin Chung, Matthew Jaconelli, Barbara Vona, Noemí Esteras, Anna Ka-Yee Kwong, Thomas Courtin, Reza Maroofian, Shahryar Alavi, Raja S Nirujogi, Mariasavina Severino, Patrick A Lewis, Stephanie Efthymiou, Benjamin J O'Callaghan, Rebecca Buchert, Linda Sofan, Pawel Lis, Chloé Pinon, Guido J Breedveld, Martin Man Chun Chui, David P Murphy, Vanessa Pitz, Mary B Makarious, Marlene Cassar, Bassem A Hassan, Sana Iftikhar, Clarissa Rocca, Peter Bauer, Michele Tinazzi, Marina Svetel, Bedia Samanci, Hasmet A Hanagasi, Basar Bilgiç, Jose A Obeso, Mónica M Kurtis, Guillaume Cogan, Ayse Nazli Basak, Güneş Kiziltan, Tuğçe Gül, Gül Yalçın Çakmaklı, Bülent Elibol, Nina Barisic, Earny Wei-Sen Ng, Sze-Shing Fan, Tova Hershkovitz, Karin Weiss, Javeria Raza Alvi, Tipu Sultan, Issam Azmi Alkhawaja, Tawfiq Froukh, Hadeel Abdollah E Alrukban, Christine Fauth, Ulrich A Schatz, Thomas Zöggeler, Michael Zech, Karen L Stals, Vinod C Varghese, Sonia Gandhi, Cornelis Blauwendraat, John A Hardy, Suzanne Lesage, Vincenzo Bonifati, Tobias B Haack, Aida Maria Bertoli-Avella, Robert Steinfeld, Dario R Alessi, Hermann Steller, Alexis Brice, Andrey Y Abramov, Kailash P Bhatia, Henry Houlden
PSMF1 variants cause a phenotypic spectrum from early-onset Parkinson's disease to perinatal lethality by disrupting mitochondrial pathways. medRxiv : the preprint server for health sciences (2024)
Shahzad S Khan, Ebsy Jaimon, Yu-En Lin, Jonas M Nikoloff, Francesca Tonelli, Dario R Alessi, Suzanne R Pfeffer
Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson's disease. bioRxiv : the preprint server for biology (2024)
Shahzad S Khan, Ebsy Jaimon, Yu-En Lin, Jonas M Nikoloff, Francesca Tonelli, Dario R Alessi, Suzanne R Pfeffer
Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson's disease. bioRxiv : the preprint server for biology (2024)
Emil Karl Gustavsson, Jordan Follett, Joanne Trinh, Sandeep Kumar Barodia, Raquel Real, Zhiyong Liu, Melissa Grant-Peters, Jesse D Fox, Silke Appel-Cresswell, A Jon Stoessl, Alex Rajput, Ali H Rajput, Roland Auer, Russel Tilney, Marc Sturm, Tobias B Haack, Suzanne Lesage, Christelle Tesson, Alexis Brice, Carles Vilariño-Güell, Mina Ryten, Matthew S Goldberg, Andrew B West, Michele Tao-Ming Hu, Huw R Morris, Manu Sharma, Ziv Gan Or, Bedia Samanci, Pawel Lis, Maria Teresa Periñán, Rim Amouri, Samia Ben Sassi, Faycel Hentati, null null, Francesca Tonelli, Dario R Alessi, Matthew J Farrer
A pathogenic variant in RAB32 causes autosomal dominant Parkinson's disease and activates LRRK2 kinase. medRxiv : the preprint server for health sciences (2024)
Carmelo Milioto, Mireia Carcolé, Ashling Giblin, Rachel Coneys, Olivia Attrebi, Mhoriam Ahmed, Samuel S Harris, Byung Il Lee, Mengke Yang, Robert A Ellingford, Raja S Nirujogi, Daniel Biggs, Sally Salomonsson, Matteo Zanovello, Paula de Oliveira, Eszter Katona, Idoia Glaria, Alla Mikheenko, Bethany Geary, Evan Udine, Deniz Vaizoglu, Sharifah Anoar, Khrisha Jotangiya, Gerard Crowley, Demelza M Smeeth, Mirjam L Adams, Teresa Niccoli, Rosa Rademakers, Marka van Blitterswijk, Anny Devoy, Soyon Hong, Linda Partridge, Alyssa N Coyne, Pietro Fratta, Dario R Alessi, Benjamin Davies, Marc Aurel Busche, Linda Greensmith, Elizabeth M C Fisher, Adrian M Isaacs
PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons. Nature neuroscience 27 (4) (2024)
Poulomi Banerjee, Arpan R Mehta, Raja S Nirujogi, James Cooper, Owen G James, Jyoti Nanda, James Longden, Karen Burr, Karina McDade, Andrea Salzinger, Evdokia Paza, Judith Newton, David Story, Suvankar Pal, Colin Smith, Dario R Alessi, Bhuvaneish T Selvaraj, Josef Priller, Siddharthan Chandran
Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72 -ALS iPSC-derived microglia contributes to neurodegeneration. Science advances 9 (16) (2023)
Herschel S Dhekne, Francesca Tonelli, Wondwossen M Yeshaw, Claire Y Chiang, Charles Limouse, Ebsy Jaimon, Elena Purlyte, Dario R Alessi, Suzanne R Pfeffer
Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase. eLife 12 (2023)
Hanwen Zhu, Francesca Tonelli, Martin Turk, Alan R Prescott, Dario R Alessi, Ji Sun
Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2. Science (New York, N.Y.) 382 (6677) (2023)
Hanwen Zhu, Francesca Tonelli, Martin Turk, Alan R Prescott, Dario R Alessi, Ji Sun
Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2. Science (New York, N.Y.) 382 (6677) (2023)
Poulomi Banerjee, Arpan R Mehta, Raja S Nirujogi, James Cooper, Owen G James, Jyoti Nanda, James Longden, Karen Burr, Karina McDade, Andrea Salzinger, Evdokia Paza, Judith Newton, David Story, Suvankar Pal, Colin Smith, Dario R Alessi, Bhuvaneish T Selvaraj, Josef Priller, Siddharthan Chandran
Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72 -ALS iPSC-derived microglia contributes to neurodegeneration. Science advances 9 (16) (2023)
Prosenjit Pal, Matthew Taylor, Yuko P Y Lam, Francesca Tonelli, Chloe A Hecht, Pawel Lis, Raja S Nirujogi, Toan K Phung, Wondwossen M Yeshaw, Ebsy Jaimon, Rotimi Yemi Fasimoye, Emily A Dickie, Melanie Wightman, Thomas J Macartney, Suzanne R Pfeffer, Dario R Alessi
Parkinson's VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B. Science advances 9 (50) (2023)
Poulomi Banerjee, Arpan R Mehta, Raja S Nirujogi, James Cooper, Owen G James, Jyoti Nanda, James Longden, Karen Burr, Karina McDade, Andrea Salzinger, Evdokia Paza, Judith Newton, David Story, Suvankar Pal, Colin Smith, Dario R Alessi, Bhuvaneish T Selvaraj, Josef Priller, Siddharthan Chandran
Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72 -ALS iPSC-derived microglia contributes to neurodegeneration. Science advances 9 (16) (2023)
Poulomi Banerjee, Arpan R Mehta, Raja S Nirujogi, James Cooper, Owen G James, Jyoti Nanda, James Longden, Karen Burr, Karina McDade, Andrea Salzinger, Evdokia Paza, Judith Newton, David Story, Suvankar Pal, Colin Smith, Dario R Alessi, Bhuvaneish T Selvaraj, Josef Priller, Siddharthan Chandran
Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72 -ALS iPSC-derived microglia contributes to neurodegeneration. Science advances 9 (16) (2023)
Rui Qi, Esther M Sammler, Claudia P Gonzalez-Hunt, Ivana Barraza, Nicholas Pena, Jeremy P Rouanet, Yahaira Naaldijk, Steven Goodson, Marie Fuzzati, Fabio Blandini, Kirk I Erickson, Andrea M Weinstein, Michael W Lutz, John B J Kwok, Glenda M Halliday, Nicolas Dzamko, Shalini Padmanabhan, Roy N Alcalay, Cheryl Waters, Penelope Hogarth, Tatyana Simuni, Danielle Smith, Connie Marras, Francesca Tonelli, Dario R Alessi, Andrew B West, Sruti Shiva, Sabine Hilfiker, Laurie H Sanders
A blood-based marker of mitochondrial DNA damage in Parkinson's disease. Science translational medicine 15 (711) (2023)
Hanwen Zhu, Francesca Tonelli, Martin Turk, Alan R Prescott, Dario R Alessi, Ji Sun
Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2. Science (New York, N.Y.) 382 (6677) (2023)
Hanwen Zhu, Francesca Tonelli, Martin Turk, Alan R Prescott, Dario R Alessi, Ji Sun
Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2. Science (New York, N.Y.) 382 (6677) (2023)
Poulomi Banerjee, Arpan R Mehta, Raja S Nirujogi, James Cooper, Owen G James, Jyoti Nanda, James Longden, Karen Burr, Karina McDade, Andrea Salzinger, Evdokia Paza, Judith Newton, David Story, Suvankar Pal, Colin Smith, Dario R Alessi, Bhuvaneish T Selvaraj, Josef Priller, Siddharthan Chandran
Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72 -ALS iPSC-derived microglia contributes to neurodegeneration. Science advances 9 (16) (2023)
Hanwen Zhu, Francesca Tonelli, Martin Turk, Alan R Prescott, Dario R Alessi, Ji Sun
Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2. Science (New York, N.Y.) 382 (6677) (2023)
Hanwen Zhu, Francesca Tonelli, Martin Turk, Alan R Prescott, Dario R Alessi, Ji Sun
Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2. Science (New York, N.Y.) 382 (6677) (2023)
Hanwen Zhu, Francesca Tonelli, Martin Turk, Alan R Prescott, Dario R Alessi, Ji Sun
Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2. Science (New York, N.Y.) 382 (6677) (2023)
Hanwen Zhu, Francesca Tonelli, Martin Turk, Alan R Prescott, Dario R Alessi, Ji Sun
Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2. Science (New York, N.Y.) 382 (6677) (2023)
Poulomi Banerjee, Arpan R Mehta, Raja S Nirujogi, James Cooper, Owen G James, Jyoti Nanda, James Longden, Karen Burr, Karina McDade, Andrea Salzinger, Evdokia Paza, Judith Newton, David Story, Suvankar Pal, Colin Smith, Dario R Alessi, Bhuvaneish T Selvaraj, Josef Priller, Siddharthan Chandran
Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72 -ALS iPSC-derived microglia contributes to neurodegeneration. Science advances 9 (16) (2023)
Poulomi Banerjee, Arpan R Mehta, Raja S Nirujogi, James Cooper, Owen G James, Jyoti Nanda, James Longden, Karen Burr, Karina McDade, Andrea Salzinger, Evdokia Paza, Judith Newton, David Story, Suvankar Pal, Colin Smith, Dario R Alessi, Bhuvaneish T Selvaraj, Josef Priller, Siddharthan Chandran
Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72 -ALS iPSC-derived microglia contributes to neurodegeneration. Science advances 9 (16) (2023)
Edmundo G Vides, Ayan Adhikari, Claire Y Chiang, Pawel Lis, Elena Purlyte, Charles Limouse, Justin L Shumate, Elena Spínola-Lasso, Herschel S Dhekne, Dario R Alessi, Suzanne R Pfeffer
A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation. eLife 11 (2022)
Alexia F Kalogeropulou, Elena Purlyte, Francesca Tonelli, Sven M Lange, Melanie Wightman, Alan R Prescott, Shalini Padmanabhan, Esther Sammler, Dario R Alessi
Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding. The Biochemical journal 479 (17) (2022)
Asad U Malik, Athanasios Karapetsas, Raja S Nirujogi, Deep Chatterjee, Toan K Phung, Melanie Wightman, Robert Gourlay, Nick Morrice, Sebastian Mathea, Stefan Knapp, Dario R Alessi
PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain. The Biochemical journal 479 (18) (2022)
Xingui Liu, Alexia F Kalogeropulou, Sofia Domingos, Nikolai Makukhin, Raja S Nirujogi, François Singh, Natalia Shpiro, Anton Saalfrank, Esther Sammler, Ian G Ganley, Rui Moreira, Dario R Alessi, Alessio Ciulli
Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2. Journal of the American Chemical Society 144 (37) (2022)
Zhuoyao Chen, Jinwei Zhang, Adrián R Murillo-de-Ozores, María Castañeda-Bueno, Francesca D'Amico, Raphael Heilig, Charlotte E Manning, Fiona J Sorrell, Vincenzo D'Angiolella, Roman Fischer, Monique P C Mulder, Gerardo Gamba, Dario R Alessi, Alex N Bullock
Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase. The Biochemical journal 479 (5) (2022)
Adam G Bond, Conner Craigon, Kwok-Ho Chan, Andrea Testa, Athanasios Karapetsas, Rotimi Yemi Fasimoye, Thomas J Macartney, J Julian Blow, Dario R Alessi, Alessio Ciulli
Development of BromoTag: A "Bump-and-Hole"-PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins. Journal of medicinal chemistry 64 (20) (2021)
Dieter Waschbüsch, Kerryn Berndsen, Pawel Lis, Axel Knebel, Yuko P Y Lam, Dario R Alessi, Amir Rafiq Khan
Structural basis for the specificity of PPM1H phosphatase for Rab GTPases. EMBO reports 22 (11) (2021)
Shahzad S Khan, Yuriko Sobu, Herschel S Dhekne, Francesca Tonelli, Kerryn Berndsen, Dario R Alessi, Suzanne R Pfeffer
Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain. eLife 10 (2021)
Anna Tasegian, Francois Singh, Ian G Ganley, Alastair D Reith, Dario R Alessi
Impact of Type II LRRK2 inhibitors on signaling and mitophagy. The Biochemical journal 478 (19) (2021)
David E Gordon, Joseph Hiatt, Mehdi Bouhaddou, Veronica V Rezelj, Svenja Ulferts, Hannes Braberg, Alexander S Jureka, Kirsten Obernier, Jeffrey Z Guo, Jyoti Batra, Robyn M Kaake, Andrew R Weckstein, Tristan W Owens, Meghna Gupta, Sergei Pourmal, Erron W Titus, Merve Cakir, Margaret Soucheray, Michael J McGregor, Zeynep Cakir, Gwendolyn M Jang, Matthew J O'Meara, Tia A Tummino, Ziyang Zhang, Helene Foussard, Ajda Rojc, Yuan Zhou, Dmitry Kuchenov, Ruth Hüttenhain, Jiewei Xu, Manon Eckhardt, Danielle L Swaney, Jacqueline M Fabius, Manisha Ummadi, Beril Tutuncuoglu, Ujjwal Rathore, Maya Modak, Paige Haas, Kelsey M Haas, Zun Zar Chi Naing, Ernst H Pulido, Ying Shi, Inigo Barrio-Hernandez, Danish Memon, Eirini Petsalaki, Alistair S Dunham, Miguel Correa Marrero, David Francis Burke, Cassandra Koh, Thomas Vallet, Jesus A Silvas, Caleigh M Azumaya, Christian B Billesbølle, Axel F Brilot, Melody G Campbell, Amy Diallo, Miles Sasha Dickinson, Devan Diwanji, Nadia Herrera, Nicholas Hoppe, Huong T Kratochvil, Yanxin Liu, Gregory E Merz, Michelle Moritz, Henry C Nguyen, Carlos A Nowotny, Cristina Puchades, Alexandrea N Rizo, Ursula Schulze-Gahmen, Amber M Smith, Ming Sun, Iris D Young, Jianhua Zhao, Daniel Asarnow, Justin T Biel, Alisa Bowen, Julian R Braxton, Jen Chen, Cynthia M Chio, Un Seng Chio, Ishan Deshpande, Loan Doan, Bryan Faust, Sebastian Flores, Mingliang Jin, Sun Kyung Kim, Victor L Lam, Fei Li, Junrui Li, Grant J Jensen, Yang Li, Xi Liu, Megan Lo, Kyle E Lopez, Arthur A Melo, Frank R Moss, Phuong Nguyen, Joana Paulino, Komal Ishwar Pawar, Jessica K Peters, Thomas H Pospiech, Maliheh Safari, Smriti Sangwan, Kaitlin Schaefer, Paul V Thomas, Aye C Thwin, Raphael Trenker, Eric Tse, Tsz Kin Martin Tsui, Feng Wang, Natalie Whitis, Zanlin Yu, Kaihua Zhang, Sunny Zhang, Fengbo Zhou, Daniel J Saltzberg, null null, Anthony J Hodder, Amber S Shun-Shion, Daniel M Williams, Kris M White, Romel Rosales, Thomas Kehrer, Lisa Miorin, Elena Moreno, Arvind H Patel, Suzannah J Rihn, Mir Mubashir Khalid, Albert Vallejo-Gracia, Parinaz Fozouni, Camille R Simoneau, Theodore L Roth, David Wu, Mohd Anisul Karim, Maya Ghoussaini, Ian Dunham, Francesco Berardi, Sebastian Weigang, Maxime Chazal, Jisoo Park, James P Logue, Marisa E McGrath, Stuart M Weston, Robert E Haupt, C James Hastie, Matthew Elliott, Fiona Brown, Kerry A Burness, Elaine Reid, Mark Dorward, Clare Johnson, Stuart G Wilkinson, Anna Geyer, Daniel M Giesel, Carla Baillie, Samantha Raggett, Hannah Leech, Rachel Toth, Nicola Goodman, Kathleen C Keough, Abigail L Lind, null null, Reyna J Klesh, Kafi R Hemphill, Jared Carlson-Stevermer, Jennifer Oki, Kevin Holden, Travis Maures, Katherine S Pollard, Andrej Sali, David A Agard, Yifan Cheng, Brian K Shoichet, Adam Frost, Natalia Jura, Tanja Kortemme, Aashish Manglik, Daniel R Southworth, Robert M Stroud, Dario R Alessi, Paul Davies, Matthew B Friemann, Trey Ideker, Carmen Abate, Nolwenn Jouvenet, Georg Kochs, Brian K Shoichet, Melanie M Ott, Massimo Palmarini, Kevan M Shokat, Adolfo García-Sastre, Jeremy A Rassen, Robert Grosse, Oren S Rosenberg, Kliment A Verba, Christopher F Basler, Marco Vignuzzi, Andrew A Peden, Pedro Beltrao, Nevan J Krogan
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science (New York, N.Y.) 370 (6521) (2020)
Roberto Di Maio, Eric K Hoffman, Emily M Rocha, Matthew T Keeney, Laurie H Sanders, Briana R de Miranda, Alevtina Zharikov, Amber D Van Laar, Antonia F Stepan, Thomas A Lanz, Julia K Kofler, Edward A Burton, Dario R Alessi, Teresa G Hastings, J Timothy Greenamyre
LRRK2 activation in idiopathic Parkinson's disease. Science translational medicine 10 (451) (2019)
Hannah Tovell, Andrea Testa, Chiara Maniaci, Houjiang Zhou, Alan R Prescott, Thomas Macartney, Alessio Ciulli, Dario R Alessi
Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader. ACS chemical biology 14 (5) (2019)
Kerryn Berndsen, Pawel Lis, Wondwossen M Yeshaw, Paulina S Wawro, Raja S Nirujogi, Melanie Wightman, Thomas Macartney, Mark Dorward, Axel Knebel, Francesca Tonelli, Suzanne R Pfeffer, Dario R Alessi
PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins. eLife 8 (2019)
Hannah Tovell, Andrea Testa, Houjiang Zhou, Natalia Shpiro, Claire Crafter, Alessio Ciulli, Dario R Alessi
Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS chemical biology 14 (9) (2019)
Jinhua Wang, Tatiana Erazo, Fleur M Ferguson, Dennis L Buckley, Nestor Gomez, Pau Muñoz-Guardiola, Nora Diéguez-Martínez, Xianming Deng, Mingfeng Hao, Walter Massefski, Oleg Fedorov, Nana Kwaku Offei-Addo, Paul M C Park, Lingling Dai, Amy DiBona, Kelly Becht, Nam Doo Kim, Michael R McKeown, Justin M Roberts, Jinwei Zhang, Taebo Sim, Dario R Alessi, James E Bradner, Jose M Lizcano, Stephen C Blacklow, Jun Qi, Xiang Xu, Nathanael S Gray
Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains. ACS chemical biology 13 (9) (2018)
Herschel S Dhekne, Izumi Yanatori, Rachel C Gomez, Francesca Tonelli, Federico Diez, Birgitt Schüle, Martin Steger, Dario R Alessi, Suzanne R Pfeffer
A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain. eLife 7 (2018)
Anetta Härtlova, Susanne Herbst, Julien Peltier, Angela Rodgers, Orsolya Bilkei-Gorzo, Antony Fearns, Brian D Dill, Heyne Lee, Rowan Flynn, Sally A Cowley, Paul Davies, Patrick A Lewis, Ian G Ganley, Jennifer Martinez, Dario R Alessi, Alastair D Reith, Matthias Trost, Maximiliano G Gutierrez
LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages. The EMBO journal 37 (12) (2018)
Chiara Maniaci, Scott J Hughes, Andrea Testa, Wenzhang Chen, Douglas J Lamont, Sonia Rocha, Dario R Alessi, Roberto Romeo, Alessio Ciulli
Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nature communications 8 (1) (2017)
Elena Purlyte, Herschel S Dhekne, Adil R Sarhan, Rachel Gomez, Pawel Lis, Melanie Wightman, Terina N Martinez, Francesca Tonelli, Suzanne R Pfeffer, Dario R Alessi
Rab29 activation of the Parkinson's disease-associated LRRK2 kinase. The EMBO journal 37 (1) (2017)
Andrew S Gilbert, Paula I Seoane, Poppy C S Sephton-Clark, Aleksandra Bojarczuk, Richard Hotham, Emanuele Giurisato, Adil R Sarhan, Amy Hillen, Greetje Vande Velde, Nathanael S Gray, Dario R Alessi, Debbie L Cunningham, Cathy Tournier, Simon A Johnston, Robin C May
Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5. Science advances 3 (8) (2017)
Aida M Lopez-Guerrero, Patricia Tomas-Martin, Carlos Pascual-Caro, Thomas Macartney, Alejandro Rojas-Fernandez, Graeme Ball, Dario R Alessi, Eulalia Pozo-Guisado, Francisco Javier Martin-Romero
Regulation of membrane ruffling by polarized STIM1 and ORAI1 in cortactin-rich domains. Scientific reports 7 (1) (2017)
Martin Steger, Federico Diez, Herschel S Dhekne, Pawel Lis, Raja S Nirujogi, Ozge Karayel, Francesca Tonelli, Terina N Martinez, Esben Lorentzen, Suzanne R Pfeffer, Dario R Alessi, Matthias Mann
Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis. eLife 6 (2017)
Ruzica Bago, Eeva Sommer, Pau Castel, Claire Crafter, Fiona P Bailey, Natalia Shpiro, José Baselga, Darren Cross, Patrick A Eyers, Dario R Alessi
The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth. The EMBO journal 35 (17) (2016)

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Dario R Alessi