Association of Neurofilament Light Chain, [ 18 F]PI-2620 Tau-PET, TSPO-PET, and Clinical Progression in Patients With β-Amyloid-Negative CBS.

Carla Palleis Nicolai Franzmeier Endy Weidinger Alexander Maximilian Bernhardt Sabrina KatzdoblerStephan WallChristian Ferschmann Stefanie Harris Julia Schmitt Sebastian Schuster Johannes Gnörich Anika Finze Gloria Biechele Simon LindnerNathalie L AlbertPeter Bartenstein Osama Sabri Henryk Barthel Rainer Rupprecht Brigitte Nuscher Andrew W Stephens Boris-Stephan Rauchmann Matthias Brendel Christian HaassMatthias BrendelJohannes Levin Günter U Höglinger

Published in: Neurology (2023)

F]GE-180 TSPO-PET, and plasma-NfL show prognostic potential for clinical progression in patients with Aβ-negative CBS with probable 4-repeat tauopathy, which can be useful for clinical decision-making and stratifying patients in clinical trials.

Keyphrases

pet imaging
clinical trial
computed tomography
pet ct
positron emission tomography
decision making
end stage renal disease
cerebrospinal fluid
randomized controlled trial
peritoneal dialysis
patient reported outcomes
study protocol
double blind
patient reported