Clinical and patient-reported outcomes of SPARE - a randomised feasibility study of selective bladder preservation versus radical cystectomy.
Robert A HuddartAlison BirtleLauren MaynardMark BeresfordJane BlazebyJenny DonovanJohn D KellyTony KirkbankDuncan B McLarenGraham MeadClare MoynihanRaj PersadChristopher ScraseRebecca LewisEmma C HallPublished in: BJU international (2017)
Randomising patients with MIBC between RC and SBP based on response to neoadjuvant chemotherapy was not feasible in the UK health system. Strong clinician and patient preferences for treatments impacted willingness to undergo randomisation and acceptance of treatment allocation. Due to the few participants, firm conclusions about disease and toxicity outcomes cannot be drawn.
Keyphrases
- neoadjuvant chemotherapy
- patient reported outcomes
- locally advanced
- lymph node
- clinical trial
- sentinel lymph node
- spinal cord injury
- open label
- case report
- oxidative stress
- study protocol
- type diabetes
- randomized controlled trial
- double blind
- squamous cell carcinoma
- rectal cancer
- cross sectional
- metabolic syndrome
- placebo controlled
- decision making
- early stage
- adipose tissue
- combination therapy
- weight loss
- oxide nanoparticles