PPAR-Responsive Elements Enriched with Alu Repeats May Contribute to Distinctive PPARγ-DNMT1 Interactions in the Genome.

Ingo G H Schmidt-Wolf Fabian Tobar-TosseTikam Chand DakalHongde Liu Arijit BiswasAthira MenonAnoosha ParuchuriPanagiostis KatsonisOlivier LichtargeM Michael Gromiha Michael LudwigIngo G H Schmidt-WolfFrank G HolzKarin U LoefflerMartina C Herwig-Carl

Published in: Cancers (2021)

We hypothesize that the function of PPARγ requires an additional contribution of Alu repeats which may directly influence the DNMT1 network. Regarding UM, PPARγ appears to be an additional discriminatory prognostic marker, in particular in disomy 3 tumors.

Keyphrases

insulin resistance
dna methylation
genome wide
adipose tissue
gene expression
type diabetes
metabolic syndrome
skeletal muscle
drug delivery