MicroRNA profiling of human primary macrophages exposed to dengue virus identifies miRNA-3614-5p as antiviral and regulator of ADAR1 expression.
Mayra Diosa-ToroLiliana Echavarría-ConsuegraJacky FlipseGeysson Javier FernándezJoost KluiverAnke van den BergSilvio Urcuqui-InchimaJolanda M SmitPublished in: PLoS neglected tropical diseases (2017)
Overall, miRNAs appear to play a limited role in DENV replication in primary human macrophages. The miRNAs that were found upregulated in DENV-infected cells did not control the production of infectious virus particles. On the other hand, miR-3614-5p, which was upregulated in DENV-negative macrophages, reduced DENV infectivity and regulated ADAR1 expression, a protein that facilitates viral replication.