Membrane and Soluble CD137 in Systemic Lupus Erythematosus: Role as Biomarkers for Disease Activity.

Fulvia CeccarelliFrancesco NatalucciAlessandra Di FilippoGiulio OlivieriChiara NapoletanoAurelia RughettiMarianna NutiIlaria Grazia ZizzariFabrizio Conti

Published in: Journal of immunology research (2023)

Our results suggest a possible involvement of CD137-CD137L axis in SLE pathogenesis, as demonstrated by higher expression of CD137 on CD4+ cells in SLE compared with HS. Furthermore, the positive correlation between SLEDAI-2K and membrane CD137 expression on CD4+ cells, as well as soluble CD137, indicates a possible use as biomarkers for disease activity.

Keyphrases

disease activity
systemic lupus erythematosus
rheumatoid arthritis
rheumatoid arthritis patients
ankylosing spondylitis
nk cells
induced apoptosis
poor prognosis
juvenile idiopathic arthritis
cell cycle arrest
cell death
signaling pathway
long non coding rna