Prognostic Value of the Pace of Tumor Progression as Assessed by Serial 18F-FDG PET/CT Scan and Liquid Biopsy in Refractory Colorectal Cancer: The CORIOLAN Trial.
Silvia CameraTugba Akin TelliErwin WoffCaroline VandeputtePashalina KehagiasThomas GuiotGabriela CritchiYacine WissamGiacomo BregniElena TrevisiAndrea PrettaChiara SentiSophia LeducParaskevas GkolfakisFrédéric HoernerFrançoise RothéFrancesco SclafaniPatrick FlamenAmelie DeleporteAlain HendliszPublished in: Cancers (2020)
In this study, approximately 1 out of 4 refractory CRC patients who were judged to have a life expectancy >12 weeks actually died within 12 weeks. Baseline assessment of WB-MATV, cfDNA, CTCs and CEA, but not early change evaluation of the same, may help to refine patient prognostication and guide management decisions.