Dopaminergic Positron Emission Tomography Imaging in the Alpha-Synuclein Preformed Fibril Model Reveals Similarities to Early Parkinson's Disease.

Vesna SossiJoseph R PattersonSiobhan McCormickChristopher J KempKathryn M MillerAnna C StollNathan KuhnMichael KubikJoseph KochmanskiKelvin C LukCaryl E Sortwell

Published in: Movement disorders : official journal of the Movement Disorder Society (2022)

The relative preservation of DA synthesis and storage compared to robust progressive deficits in DAT density and increases in DA turnover in the rat α-syn PFF model display remarkable face validity to dopaminergic alterations in human PD. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

positron emission tomography
computed tomography
endothelial cells
multiple sclerosis
high resolution
traumatic brain injury
pet ct
pet imaging
bone mineral density
randomized controlled trial
induced pluripotent stem cells
pluripotent stem cells
photodynamic therapy
postmenopausal women
meta analyses