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Effect of high altitude on human postprandial 13 C-octanoate metabolism, intermediary metabolites, gastrointestinal peptides, and visceral perception.

Patrick-Pascal StrunzRaphael N Vuille-Dit-BilleMark R FoxAndreas GeierMarco MaggioriniMax GassmannHeiko FruehaufThomas A LutzOliver Goetze
Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2021)
Quantification of 13 C-octanoate oxidation by a breath test is sensitive to variation in metabolic (liver) function under hypoxic conditions. 13 C-breath testing using short-chain fatty acids is not reliable for measurement of gastric function at HA and should be considered critically in other severe hypoxic conditions, like sepsis or chronic lung disease.
Keyphrases
  • fatty acid
  • endothelial cells
  • acute kidney injury
  • insulin resistance
  • early onset
  • hydrogen peroxide
  • blood glucose
  • septic shock
  • pluripotent stem cells
  • adipose tissue
  • skeletal muscle