Lupus serum induces inflammatory interaction with neutrophils in human glomerular endothelial cells.
Dayvia A RussellMargaret MarkiewiczJim C OatesPublished in: Lupus science & medicine (2021)
SLE serum induces expression of mediators by HRGECs that promote neutrophil chemotaxis and adhesion, which increases during disease activity, and associates with factors common to pathways of endoplasmic reticulum and oxidative stress. These findings highlight the potential importance of serum factor-induced ECD in SLE and LN.
Keyphrases
- disease activity
- systemic lupus erythematosus
- endothelial cells
- high glucose
- rheumatoid arthritis
- oxidative stress
- rheumatoid arthritis patients
- ankylosing spondylitis
- endoplasmic reticulum
- juvenile idiopathic arthritis
- diabetic rats
- poor prognosis
- vascular endothelial growth factor
- escherichia coli
- staphylococcus aureus
- induced apoptosis
- cystic fibrosis
- biofilm formation
- signaling pathway
- diabetic nephropathy
- heat stress