Multi-omics Integration Analysis Robustly Predicts High-Grade Patient Survival and Identifies CPT1B Effect on Fatty Acid Metabolism in Bladder Cancer.
Venkatrao VantakuJianrong DongChandrashekar R AmbatiDimuthu PereraSri Ramya DonepudiChandra Sekhar AmaraVasanta PutluriShiva Shankar RaviMatthew J RobertsonDanthasinghe Waduge Badrajee PiyarathnaMariana VillanuevaFriedrich-Carl von RundstedtBalasubramanyam KaranamLeomar Y BallesterMartha K TerrisRoni J BollagSeth P LernerAndrea B ApoloMin Jae LeeAndrew G SikoraYair LotanArun SreekumarCristian CoarfaNagireddy PutluriPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Our study demonstrates a novel approach for the integration of metabolomics, lipidomics, and transcriptomics data, and identifies a common gene signature associated with poor survival in patients with bladder cancer. Our data also suggest that impairment of FAO due to downregulation of CPT1B plays an important role in the progression toward high-grade bladder cancer and provide potential targets for therapeutic intervention.