TLR expression in peripheral monocyte subsets of patients with idiopathic inflammatory myopathies: association with clinical and immunological features.
Jiram Torres-RuizDaniel Alberto Carrillo-VazquezDiana Marcela Padilla-OrtizRicardo Vazquez-RodriguezCarlos Nuñez-AlvarezGuillermo Juarez-VegaDiana Gomez-MartinPublished in: Journal of translational medicine (2020)
Patients with IIM have a differential pool of monocyte subsets with an enhanced expression of TLR2 and TLR4, which correlates with disease activity and distinctive clinical features including dysphagia, ILD, vasculopathy, and pro-inflammatory cytokines. These immunological features might be useful as a potential diagnostic tool as well as novel disease activity biomarkers in IIM.
Keyphrases
- disease activity
- rheumatoid arthritis
- systemic lupus erythematosus
- rheumatoid arthritis patients
- toll like receptor
- ankylosing spondylitis
- peripheral blood
- inflammatory response
- poor prognosis
- immune response
- juvenile idiopathic arthritis
- dendritic cells
- interstitial lung disease
- endothelial cells
- nuclear factor
- binding protein
- anti inflammatory
- climate change
- idiopathic pulmonary fibrosis