Efficacy of PD-(L)1 blockade monotherapy compared with PD-(L)1 blockade plus chemotherapy in first-line PD-L1-positive advanced lung adenocarcinomas: a cohort study.
Arielle ElkriefJoao M Victor AlessiBiagio RicciutiSamantha BrownHira RizviIsabel R PreeshagulXinan WangFederica PecciAlessandro Di FedericoGiuseppe LambertiJacklynn V EggerJamie E ChaftCharles M RudinGregory J RielyMark G KrisMarc LadanyiYuan ChenMatthew D HellmannRonglai ShenMark M AwadAdam J SchoenfeldPublished in: Journal for immunotherapy of cancer (2023)
While the addition of chemotherapy to PD-(L)1 blockade increases the probability of initial response, never-smokers with tumor PD-L1≥50% comprise the only population identified that derived an apparent survival benefit with treatment intensification.