Endogenously-Activated Ultrasmall-in-Nano Therapeutics: Assessment on 3D Head and Neck Squamous Cell Carcinomas.
Melissa SantiAna Katrina MapanaoDomenico CassanoYlea VlamidisValentina CappelloValerio VolianiPublished in: Cancers (2020)
Negative or positive HPV-associated Head and Neck Squamous Cell Carcinomas (HNSCCs) are high recurrence neoplasms usually resulting in a poor prognosis, mainly due to metastasis formation. Despite the low overall patient survival rate and the severe side effects, the treatment of choice is still cisplatin-based chemotherapy. Here, we report a straightforward protocol for the production of high throughput 3D models of negative or positive HPV-associated HNSCCs, together with their employment in the therapeutic evaluation of gold ultrasmall-in-nano architectures comprising an endogenously-activatable cisplatin prodrug. Beyond enhancing the biosafety of cisplatin, our approach paves the way for the establishment of synergistic co-therapies for HNSCCs based on excretable noble metals.
Keyphrases
- squamous cell
- poor prognosis
- high grade
- high throughput
- long non coding rna
- cancer therapy
- free survival
- randomized controlled trial
- case report
- small molecule
- iron oxide
- health risk
- fluorescent probe
- risk assessment
- locally advanced
- human health
- drug release
- climate change
- mental illness
- iron oxide nanoparticles
- decision making
- health risk assessment