Downregulation of microRNA-124-3p promotes subventricular zone neural stem cell activation by enhancing the function of BDNF downstream pathways after traumatic brain injury in adult rats.
En-Ming KangYi-Bin JiaJia-You WangGuan-Yi WangHui-Jun ChenXiao-Yan ChenYu-Qin YeXin ZhangXin-Hong SuJing-Yu WangXiao-Sheng HePublished in: CNS neuroscience & therapeutics (2022)
Disrupting miR-124 expression through lateral ventricle injection has beneficial effects on neuroregeneration and TBI prognosis. Moreover, the combined use of BDNF and miR-124 inhibitors might lead to better outcomes in TBI than BDNF treatment alone.
Keyphrases
- cell proliferation
- long non coding rna
- traumatic brain injury
- stem cells
- poor prognosis
- stress induced
- long noncoding rna
- severe traumatic brain injury
- mild traumatic brain injury
- pulmonary hypertension
- mitral valve
- pulmonary artery
- minimally invasive
- heart failure
- type diabetes
- combination therapy
- ultrasound guided
- young adults
- congenital heart disease
- coronary artery
- mesenchymal stem cells
- pulmonary arterial hypertension
- cell therapy