CBLB ablation with CRISPR/Cas9 enhances cytotoxicity of human placental stem cell-derived NK cells for cancer immunotherapy.
Xuan GuoTanel MahlakõivQian YeSrinivas SomanchiShuyang HeHemlata RanaAndrea DiFigliaJoseph GleasonWilliam van der TouwRobert HaririXiaokui ZhangPublished in: Journal for immunotherapy of cancer (2021)
CBLB ablation increased PNK cell effector function and proliferative capacity compared with non-modified PNK cells. These data suggest that targeting CBLB may offer therapeutic advantages via enhancing antitumor activities of NK cell therapies.
Keyphrases
- nk cells
- crispr cas
- induced apoptosis
- endothelial cells
- genome editing
- cell cycle arrest
- single cell
- radiofrequency ablation
- cell therapy
- electronic health record
- regulatory t cells
- induced pluripotent stem cells
- catheter ablation
- dendritic cells
- big data
- endoplasmic reticulum stress
- stem cells
- pluripotent stem cells
- drug delivery
- signaling pathway
- machine learning
- artificial intelligence