Blood product transfusion and lung transplant outcomes: A systematic review.
Jacob A KlapperAnne C HicksLeila LedbetterJessica PoissonMatthew G HartwigNazish HashmiIan WelsbyBrandi A BottigerPublished in: Clinical transplantation (2021)
The perioperative transfusion of blood products has long been linked to development of acute lung injury and associated with mortality across both medical and surgical patient populations.1,2 The need for blood product transfusion during and after lung transplantation is common and, in many instances, unavoidable. However, this practice may potentially be modifiable.3 In this systematic review, we explore and summarize what is known regarding the impact of blood product transfusion on outcomes following lung transplantation, highlighting the most recent work in this area. Overall, the majority of the literature consists of single center retrospective analyses or the work of multicenter working groups referencing the same database. In the end, there are a number of remaining questions regarding blood product transfusion and their downstream effects on graft function and survival.
Keyphrases
- cardiac surgery
- systematic review
- sickle cell disease
- healthcare
- acute kidney injury
- primary care
- cross sectional
- type diabetes
- randomized controlled trial
- emergency department
- metabolic syndrome
- skeletal muscle
- adipose tissue
- inflammatory response
- case report
- insulin resistance
- risk factors
- coronary artery disease
- weight loss
- glycemic control