The Spatial Landscape of Progression and Immunoediting in Primary Melanoma at Single-Cell Resolution.

Ajit J Nirmal Zoltan Maliga Tuulia ValliusBrian QuattrochiAlyce A Chen Connor A Jacobson Roxanne J Pelletier Clarence Yapp Raquel Arias-Camison Yu-An Chen Christine G LianGeorge F MurphySandro Santagata Peter Karl Sorger

Published in: Cancer discovery (2022)

The reorganization of the tumor ecosystem in primary melanoma is an excellent setting in which to study immunoediting and immune evasion. Guided by classic histopathology, spatial profiling of proteins and mRNA reveals recurrent morphologic and molecular features of tumor evolution that involve localized paracrine cytokine signaling and direct cell-cell contact. This article is highlighted in the In This Issue feature, p. 1397.

Keyphrases

single cell
rna seq
high throughput
cell therapy
machine learning
climate change
deep learning
stem cells
risk assessment
bone marrow