MicroRNAs modulate SARS-CoV-2 infection of primary human hepatocytes by regulating the entry factors ACE2 and TMPRSS2.

Rajendra KhanalNatalie HeinenAlexandra BogomolovaToni L MeisterSimon T HerrmannSaskia WesthovenMaximilian K NockeDaniel TodtFreya JockenhövelIsabel M KleinLaura HartmannFlorian W R VondranEike SteinmannGert ZimmerMichael OttRichard J P BrownAmar Deep SharmaStephanie Pfaender

Published in: Liver international : official journal of the International Association for the Study of the Liver (2024)

We confirm that PHH are susceptible to SARS-CoV-2 infection and demonstrate selected miRNAs targeting SARS-CoV-2 entry factors and/or the viral genome reduce viral loads. These data provide novel insights into hepatic susceptibility to SARS-CoV-2 and associated dysfunctions in COVID-19.

Keyphrases

sars cov
respiratory syndrome coronavirus
endothelial cells
electronic health record
coronavirus disease
angiotensin ii
cancer therapy
big data
gene expression
pluripotent stem cells
liver injury
deep learning
drug induced