Expression of myxovirus-resistance protein A: a possible marker of muscle disease activity and autoantibody specificities in juvenile dermatomyositis.
S SoponkanapornC T DeakinP W SchutzL R MarshallS A YasinC M JohnsonE SagS L TansleyN J McHughLucy R WedderburnThomas S JacquesPublished in: Neuropathology and applied neurobiology (2018)
This study reveals the significant association between level of MxA expression on muscle fibres and clinical measures of muscular disease activity in JDM patients and MSA status. This confirms type I interferonopathies in muscle fibres of JDM patients which could help with improving treatment outcome in JDM patients and underscoring the distinct pathophysiological pathways in different MSA status.
Keyphrases
- disease activity
- end stage renal disease
- rheumatoid arthritis
- newly diagnosed
- ejection fraction
- chronic kidney disease
- skeletal muscle
- rheumatoid arthritis patients
- poor prognosis
- peritoneal dialysis
- ankylosing spondylitis
- juvenile idiopathic arthritis
- long non coding rna
- systemic sclerosis
- body composition
- resistance training
- patient reported
- idiopathic pulmonary fibrosis