Brief assessment of cognitive function in myotonic dystrophy: Multicenter longitudinal study using computer-assisted evaluation.
Gayle K DeutschKatharine A HagermanJacinda SampsonGersham DentJeanne DekdebrunDana M ParkerCharles A ThorntonChad R HeatwoleSub H SubramonyAmi K MankodiTetsuo AshizawaJeffrey M StatlandW David ArnoldRichard T MoxleyJohn W Daynull nullPublished in: Muscle & nerve (2022)
Computerized tests of cognition are feasible in multicenter studies of DM1. Poor performance was exhibited in working memory, which may be a useful variable in clinical trials. Learning effects may have contributed to the improvement in executive functioning. The relationship between PROs and cognitive impairment in DM1 requires further study.
Keyphrases
- working memory
- cognitive impairment
- clinical trial
- cross sectional
- transcranial direct current stimulation
- attention deficit hyperactivity disorder
- double blind
- early onset
- mild cognitive impairment
- type diabetes
- glycemic control
- randomized controlled trial
- multiple sclerosis
- metabolic syndrome
- case control
- phase ii
- open label
- study protocol