Multimodal intrathecal analgesia (MITA) with morphine for reducing postoperative opioid use and acute pain following hepato-pancreato-biliary surgery: A multicenter retrospective study.
Vidhura RatnasekaraLaurence WeinbergSamuel Anthony JohnstonLuke R FletcherPatrick NugrahaDaniel Robert Anthony CoxRaymond T HuIlonka MeyerOsamu YoshinoMarcos Vinius PeriniVijayaragavan MuralidharanMehrdad NikfarjamDong-Kyu LeePublished in: PloS one (2023)
In patients undergoing complex HPB surgery, the use of MITA, consisting of ITM in combination with intrathecal clonidine and bupivacaine, was associated with reduced postoperative opioid use and resulted in superior postoperative analgesia without risk of respiratory depression when compared to patients who received ITM alone. A randomized prospective clinical trial investigating these two intrathecal analgesic techniques is justified.
Keyphrases
- patients undergoing
- pain management
- minimally invasive
- postoperative pain
- clinical trial
- coronary artery bypass
- chronic pain
- neuropathic pain
- liver failure
- surgical site infection
- double blind
- respiratory failure
- randomized controlled trial
- open label
- intensive care unit
- phase ii
- extracorporeal membrane oxygenation
- spinal cord
- anti inflammatory
- study protocol
- hepatitis b virus
- cross sectional
- physical activity
- acute coronary syndrome