Interactive enhancer hubs (iHUBs) mediate transcriptional reprogramming and adaptive resistance in pancreatic cancer.

Feda H HamdanAmro M AbdelrahmanAna Patricia KutschatXin WangThomas L EkstromNidhi Jalan-SakrikarCatherine Wegner WippelNegar TaheriLiezel TamonWaltraut KoppJoana Aggrey-FynnAditya V BhagwateRoberto Alva-RuizIsaac LynchJennifer YonkusRobyn Laura KosinskyJochen GaedckeStephan A Hahn Jens Thomas SivekeRondell GrahamZeynab NajafovaElisabeth HessmannMark J TrutySteven A Johnsen

Published in: Gut (2023)

Our findings identify an important role for a subgroup of highly connected enhancers (iHUBs) in regulating chemotherapy response and demonstrate targetability in sensitisation to chemotherapy.

Keyphrases

locally advanced
transcription factor
gene expression
randomized controlled trial
chemotherapy induced
radiation therapy
oxidative stress
phase iii
study protocol
double blind