Design of vaccine efficacy trials during public health emergencies.

Natalie E DeanPierre-Stéphane GsellRonald S BrookmeyerVictor De GruttolaChristl A DonnellyM Elizabeth HalloranMomodou JassehMartha C NasonXimena RiverosConall H WatsonAna Maria Henao-RestrepoIra M Longini

Published in: Science translational medicine (2020)

Public health emergencies, such as an Ebola disease outbreak, provide a complex and challenging environment for the evaluation of candidate vaccines. Here, we outline the need for flexible and responsive vaccine trial designs to be used in public health emergencies, and we summarize recommendations for their use in this setting.

Keyphrases

public health
global health
clinical trial
study protocol
randomized controlled trial
clinical practice