The effects of expression of different microRNAs on insulin secretion and diabetic nephropathy progression.
Alireza MafiEsmat AghadavodNaghmeh MirhosseiniMoein MobiniZatollah AsemiPublished in: Journal of cellular physiology (2018)
MicroRNAs (miRNAs) have recently become well-known efficacious biomarkers for the diagnosis of diabetic nephropathy (DN). MiRNAs, short noncoding RNAs, are posttranscriptional regulators of gene expression, which regulate several biological cell functions, including insulin production and secretion, as well as insulin resistance in tissues. Today, the focus of the medical world is centered on the role of miRNAs as mediators for different diseases, such as DN and end-stage renal diseases (ESRD). MiRNAs are stable and detectable in human biological fluids, so their detection for early diagnosis of different diseases is highly sensitive and specific. Previous reports have shown that the alteration of miRNA profiles significantly correlates with specific stages of DN, kidney fibrosis, and renal dysfunction. This review was aimed at assessing the pathway of different miRNA expressions responsible for insulin secretion disorder and DN progression.
Keyphrases
- diabetic nephropathy
- gene expression
- type diabetes
- endothelial cells
- healthcare
- poor prognosis
- single cell
- transcription factor
- emergency department
- stem cells
- label free
- metabolic syndrome
- high resolution
- binding protein
- induced pluripotent stem cells
- long non coding rna
- mass spectrometry
- mesenchymal stem cells
- pluripotent stem cells
- living cells
- end stage renal disease
- quantum dots
- peritoneal dialysis