Metabolic stress induces GD2+ cancer stem cell-like phenotype in triple-negative breast cancer.
Appalaraju JaggupilliStanley LyKhoa NguyenVivek AnandBin YuanFouad El-DanaYuanqing YanZoe ArvanitisDanthasinghe Waduge Badrajee PiyarathnaNagireddy PutluriHelen Piwnica-WormsHenry Charles ManningMichael AndreeffVenkata Lokesh BattulaPublished in: British journal of cancer (2021)
Here, we show metabolic stress results in GD2+ BCSC phenotype in TNBC and glutamine contributes to GD2+ phenotype, and targeting the glutamine transporters could complement conventional chemotherapy in TNBC.