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Metabolic stress induces GD2+ cancer stem cell-like phenotype in triple-negative breast cancer.

Appalaraju JaggupilliStanley LyKhoa NguyenVivek AnandBin YuanFouad El-DanaYuanqing YanZoe ArvanitisDanthasinghe Waduge Badrajee PiyarathnaNagireddy PutluriHelen Piwnica-WormsHenry Charles ManningMichael AndreeffVenkata Lokesh Battula
Published in: British journal of cancer (2021)
Here, we show metabolic stress results in GD2+ BCSC phenotype in TNBC and glutamine contributes to GD2+ phenotype, and targeting the glutamine transporters could complement conventional chemotherapy in TNBC.
Keyphrases
  • cancer stem cells
  • stress induced
  • squamous cell carcinoma
  • radiation therapy
  • heat stress