Intestinal peroxisome proliferator-activated receptor α-fatty acid-binding protein 1 axis modulates nonalcoholic steatohepatitis.

Tingting YanYuhong LuoNana YanKeisuke HamadaNan ZhaoYangliu XiaPing WangChangdong ZhaoDan QiShoumei YangLulu SunJie CaiQiong WangChangtao JiangOksana GavrilovaKristopher W KrauszDaxesh P PatelXiaoting YuXuan WuHai-Ping HaoWeiwei LiuAijuan QuFrank J Gonzalez

Published in: Hepatology (Baltimore, Md.) (2022)

Intestinal PPARα signaling promotes NASH progression through regulating dietary fatty acid uptake through modulation of FABP1, which provides a compelling therapeutic target for NASH treatment.

Keyphrases

fatty acid
binding protein
metabolic syndrome
combination therapy
adipose tissue
smoking cessation