Frank J Gonzalez

ORCID

Publication Activity (10 Years)

Years Active: 2015-2023
Publications (10 Years): 45

Top Venues

Nature communications

Hepatology (Baltimore, Md.)

Hepatology communications

Nature medicine

National Cancer Institute

University of Wisconsin Madison (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

National Cancer Institute Nov 1o 1984

United States

Chief :: Laboratory of Metabolism

Education History

University of Wisconsin Madison Sep 1o 1977 - May 31o 1981

United States

PHD :: Oncology

Publications

Rachel M Golonka, Beng San Yeoh, Piu Saha, Amira Gohara, Ramakumar Tummala, Stanislaw Stepkowski, Amit K Tiwari, Bina Joe, Frank J Gonzalez, Andrew T Gewirtz, Matam Vijay-Kumar
Loss of toll-like receptor 5 potentiates spontaneous hepatocarcinogenesis in farnesoid X receptor-deficient mice. Hepatology communications 7 (6) (2023)
Lulu Sun, Yi Zhang, Jie Cai, Bipin Rimal, Edson R Rocha, James P Coleman, Chenran Zhang, Robert G Nichols, Yuhong Luo, Bora Kim, Yaozong Chen, Kristopher W Krausz, Curtis C Harris, Andrew D Patterson, Zhipeng Zhang, Shogo Takahashi, Frank J Gonzalez
Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer. Nature communications 14 (1) (2023)
Lulu Sun, Yi Zhang, Jie Cai, Bipin Rimal, Edson R Rocha, James P Coleman, Chenran Zhang, Robert G Nichols, Yuhong Luo, Bora Kim, Yaozong Chen, Kristopher W Krausz, Curtis C Harris, Andrew D Patterson, Zhipeng Zhang, Shogo Takahashi, Frank J Gonzalez
Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer. Nature communications 14 (1) (2023)
Lijun Gong, Fang Wei, Frank J Gonzalez, Guolin Li
Hepatic fibrosis: targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines. Hepatology (Baltimore, Md.) (2023)
Lijun Gong, Fang Wei, Frank J Gonzalez, Guolin Li
Hepatic fibrosis: targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines. Hepatology (Baltimore, Md.) (2023)
Kai Wang, Zhiwei Zhang, Jing Hang, Jia Liu, Fusheng Guo, Yong Ding, Meng Li, Qixing Nie, Jun Lin, Yingying Zhuo, Lulu Sun, Xi Luo, Qihang Zhong, Chuan Ye, Chuyu Yun, Yi Zhang, Jue Wang, Rui Bao, Yanli Pang, Guang Wang, Frank J Gonzalez, Xiaoguang Lei, Jie Qiao, Chang-Tao Jiang
Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target. Science (New York, N.Y.) 381 (6657) (2023)
Lijun Gong, Fang Wei, Frank J Gonzalez, Guolin Li
Hepatic fibrosis: targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines. Hepatology (Baltimore, Md.) (2023)
Lulu Sun, Yi Zhang, Jie Cai, Bipin Rimal, Edson R Rocha, James P Coleman, Chenran Zhang, Robert G Nichols, Yuhong Luo, Bora Kim, Yaozong Chen, Kristopher W Krausz, Curtis C Harris, Andrew D Patterson, Zhipeng Zhang, Shogo Takahashi, Frank J Gonzalez
Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer. Nature communications 14 (1) (2023)
Lulu Sun, Yi Zhang, Jie Cai, Bipin Rimal, Edson R Rocha, James P Coleman, Chenran Zhang, Robert G Nichols, Yuhong Luo, Bora Kim, Yaozong Chen, Kristopher W Krausz, Curtis C Harris, Andrew D Patterson, Zhipeng Zhang, Shogo Takahashi, Frank J Gonzalez
Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer. Nature communications 14 (1) (2023)
Qi Zhao, Man-Yun Dai, Ruo-Yue Huang, Jing-Yi Duan, Ting Zhang, Wei-Min Bao, Jing-Yi Zhang, Shao-Qiang Gui, Shu-Min Xia, Cong-Ting Dai, Ying-Mei Tang, Frank J Gonzalez, Fei Li
Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice. Nature communications 14 (1) (2023)
Emily Van Syoc, Michelle Pistner Nixon, Justin D Silverman, Yuhong Luo, Frank J Gonzalez, Ilze Elbere, Janis Klovins, Andrew D Patterson, Connie J Rogers, Erika Ganda
Changes in the gut mycobiome are associated with Type 2 diabetes mellitus and metformin treatment across populations. bioRxiv : the preprint server for biology (2023)
Lulu Sun, Yi Zhang, Jie Cai, Bipin Rimal, Edson R Rocha, James P Coleman, Chenran Zhang, Robert G Nichols, Yuhong Luo, Bora Kim, Yaozong Chen, Kristopher W Krausz, Curtis C Harris, Andrew D Patterson, Zhipeng Zhang, Shogo Takahashi, Frank J Gonzalez
Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer. Nature communications 14 (1) (2023)
Lijun Gong, Fang Wei, Frank J Gonzalez, Guolin Li
Hepatic fibrosis: targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines. Hepatology (Baltimore, Md.) (2023)
Lulu Sun, Yi Zhang, Jie Cai, Bipin Rimal, Edson R Rocha, James P Coleman, Chenran Zhang, Robert G Nichols, Yuhong Luo, Bora Kim, Yaozong Chen, Kristopher W Krausz, Curtis C Harris, Andrew D Patterson, Zhipeng Zhang, Shogo Takahashi, Frank J Gonzalez
Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer. Nature communications 14 (1) (2023)
Lijun Gong, Fang Wei, Frank J Gonzalez, Guolin Li
Hepatic fibrosis: targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines. Hepatology (Baltimore, Md.) (2023)
Emily C Gentry, Stephanie L Collins, Morgan Panitchpakdi, Pedro Belda-Ferre, Allison K Stewart, Marvic Carrillo Terrazas, Hsueh-Han Lu, Simone Zuffa, Tingting Yan, Julian Avila Pacheco, Damian Rafal Plichta, Allegra T Aron, Mingxun Wang, Alan K Jarmusch, Fuhua Hao, Mashette Syrkin-Nikolau, Hera Vlamakis, Ashwin N Ananthakrishnan, Brigid Boland, Amy Hemperly, Niels Vande Casteele, Frank J Gonzalez, Andrew T Chan, Ramnik J Xavier, Hiutung Chu, Erin S Baker, Andrew D Patterson, Rob Knight, Dionicio Siegel, Pieter C Dorrestein
Reverse metabolomics for the discovery of chemical structures from humans. Nature (2023)
Lijun Gong, Fang Wei, Frank J Gonzalez, Guolin Li
Hepatic fibrosis: targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines. Hepatology (Baltimore, Md.) (2023)
Lijun Gong, Fang Wei, Frank J Gonzalez, Guolin Li
Hepatic fibrosis: targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines. Hepatology (Baltimore, Md.) (2023)
Bandar D Alrehaili, Mikang Lee, Shogo Takahashi, Robert Novak, Bipin Rimal, Shannon Boehme, Samuel A J Trammell, Trisha J Grevengoed, Devendra Kumar, Yazen Alnouti, Katya Chiti, Xinwen Wang, Andrew D Patterson, John Y L Chiang, Frank J Gonzalez, Yoon-Kwang Lee
Bile acid conjugation deficiency causes hypercholanemia, hyperphagia, islet dysfunction, and gut dysbiosis in mice. Hepatology communications 6 (10) (2022)
Ravikanth Nanduri, Takashi Furusawa, Alexei Lobanov, Bing He, Carol Xie, Kimia Dadkhah, Michael C Kelly, Oksana Gavrilova, Frank J Gonzalez, Michael Bustin
Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins. Nature communications 13 (1) (2022)
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W Krausz, Daxesh P Patel, Xiaoting Yu, Xuan Wu, Hai-Ping Hao, Weiwei Liu, Aijuan Qu, Frank J Gonzalez
Intestinal peroxisome proliferator-activated receptor α-fatty acid-binding protein 1 axis modulates nonalcoholic steatohepatitis. Hepatology (Baltimore, Md.) (2022)
Jie Jiang, Yuandi Ma, Yameng Liu, Dasheng Lu, Xiaoxia Gao, Kristopher W Krausz, Dhimant Desai, Shantu G Amin, Andrew D Patterson, Frank J Gonzalez, Carol Xie
Glycine-β-muricholic acid antagonizes the intestinal farnesoid X receptor-ceramide axis and ameliorates NASH in mice. Hepatology communications 6 (12) (2022)
Thomas J Velenosi, Kristopher W Krausz, Keisuke Hamada, Tiffany H Dorsey, Stefan Ambs, Shogo Takahashi, Frank J Gonzalez
Pharmacometabolomics reveals urinary diacetylspermine as a biomarker of doxorubicin effectiveness in triple negative breast cancer. NPJ precision oncology 6 (1) (2022)
Bo Chen, Lulu Sun, Guangyi Zeng, Zhe Shen, Kai Wang, Limin Yin, Feng Xu, Pengcheng Wang, Yong Ding, Qixing Nie, Qing Wu, Zhiwei Zhang, Jialin Xia, Jun Lin, Yuhong Luo, Jie Cai, Kristopher W Krausz, Ruimao Zheng, Yanxue Xue, Ming-Hua Zheng, Yang Li, Chaohui Yu, Frank J Gonzalez, Chang-Tao Jiang
Gut bacteria alleviate smoking-related NASH by degrading gut nicotine. Nature 610 (7932) (2022)
Liat Goldberg, Vijay Negi, Yang Jo Chung, Masahiro Onozawa, Yuelin J Zhu, Robert L Walker, Rachel Pierce, Daxesh P Patel, Kristopher W Krausz, Frank J Gonzalez, Margaret A Goodell, Benjamin A T Rodriguez, Paul S Meltzer, Peter D Aplan
Mutant Idh2 Cooperates with a NUP98-HOXD13 Fusion to Induce Early Immature Thymocyte Precursor ALL. Cancer research 81 (19) (2021)
Yuhong Luo, Shoumei Yang, Xuan Wu, Shogo Takahashi, Lulu Sun, Jie Cai, Kristopher W Krausz, Xiaozhen Guo, Henrique B Dias, Oksana Gavrilova, Cen Xie, Chang-Tao Jiang, Weiwei Liu, Frank J Gonzalez
Intestinal MYC modulates obesity-related metabolic dysfunction. Nature metabolism 3 (7) (2021)
Sarah S Geiger, Javier Traba, Nathan Richoz, Taylor K Farley, Stephen R Brooks, Franziska Petermann, Lingdi Wang, Frank J Gonzalez, Michael N Sack, Richard M Siegel
Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling. Nature communications 12 (1) (2021)
Jung-Hwan Kim, Tsutomu Matsubara, Jaekwon Lee, Cristina Fenollar-Ferrer, Kyungreem Han, Donghwan Kim, Shang Jia, Christopher J Chang, Heejung Yang, Tomokazu Nagano, Kristopher W Krausz, Sun-Hee Yim, Frank J Gonzalez
Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis. Nature communications 12 (1) (2021)
Yangliu Xia, Ping Wang, Nana Yan, Frank J Gonzalez, Tingting Yan
Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3. Cell death & disease 12 (2) (2021)
Lulu Sun, Jie Cai, Frank J Gonzalez
The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer. Nature reviews. Gastroenterology & hepatology 18 (5) (2021)
Edgor Cole Tolledo, Marlaina R Stocco, Sharon Miksys, Frank J Gonzalez, Rachel Fynvola Tyndale
Human CYP2D6 Is Functional in Brain In Vivo: Evidence from Humanized CYP2D6 Transgenic Mice. Molecular neurobiology 57 (6) (2020)
Jiyu Zhou, Shuang Cui, Qingxian He, Yitong Guo, Xiaojie Pan, Pengfei Zhang, Ningning Huang, Chaoliang Ge, Guang-Ji Wang, Frank J Gonzalez, Hong Wang, Hai-Ping Hao
SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis. Nature communications 11 (1) (2020)
Marlaina R Stocco, Edgor Cole Tolledo, Fariba Baghai Wadji, Frank J Gonzalez, Sharon Miksys, Rachel Fynvola Tyndale
Human CYP2D6 in the Brain Is Protective Against Harmine-Induced Neurotoxicity: Evidence from Humanized CYP2D6 Transgenic Mice. Molecular neurobiology 57 (11) (2020)
Chad N Brocker, Donghwan Kim, Tisha Melia, Kritika Karri, Thomas J Velenosi, Shogo Takahashi, Daisuke Aibara, Jessica A Bonzo, Moshe Levi, David J Waxman, Frank J Gonzalez
Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting. Nature communications 11 (1) (2020)
Edgor Cole Tolledo, Sharon Miksys, Frank J Gonzalez, Rachel Fynvola Tyndale
Propranolol is a mechanism-based inhibitor of CYP2D and CYP2D6 in humanized CYP2D6-transgenic mice: Effects on activity and drug responses. British journal of pharmacology 177 (3) (2020)
Xinyu Qi, Chuyu Yun, Lulu Sun, Jialin Xia, Qing Wu, Ying Wang, Lina Wang, Yangming Zhang, Xianyi Liang, Liying Wang, Frank J Gonzalez, Andrew D Patterson, Huiying Liu, Liangshan Mu, Zehong Zhou, Yue Zhao, Rong Li, Ping Liu, Chao Zhong, Yanli Pang, Chang-Tao Jiang, Jie Qiao
Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome. Nature medicine 25 (8) (2019)
Chiara Sartor, Laura Bachelot, Cécile Godard, Franck Lager, Gilles Renault, Frank J Gonzalez, Christine Perret, Angelique Gougelet, Sabine Colnot
The concomitant loss of APC and HNF4α in adult hepatocytes does not contribute to hepatocarcinogenesis driven by β-catenin activation. Liver international : official journal of the International Association for the Study of the Liver 39 (4) (2019)
Chirag N Patel, Sivakumar Prasanth Kumar, Rakesh M Rawal, Daxesh P Patel, Frank J Gonzalez, Himanshu A Pandya
A multiparametric organ toxicity predictor for drug discovery. Toxicology mechanisms and methods 30 (3) (2019)
Qi Zhao, Ting Zhang, Xue-Rong Xiao, Jian-Feng Huang, Yan Wang, Frank J Gonzalez, Fei Li
Impaired clearance of sunitinib leads to metabolic disorders and hepatotoxicity. British journal of pharmacology 176 (13) (2019)
Lulu Sun, Cen Xie, Guang Wang, Yue Wu, Qing Wu, Xuemei Wang, Jia Liu, Yangyang Deng, Jialin Xia, Bo Chen, Songyang Zhang, Chuyu Yun, Guan Lian, Xiujuan Zhang, Heng Zhang, William H Bisson, Jingmin Shi, Xiaoxia Gao, Pupu Ge, Cuihua Liu, Kristopher W Krausz, Robert G Nichols, Jingwei Cai, Bipin Rimal, Andrew D Patterson, Xian Wang, Frank J Gonzalez, Chang-Tao Jiang
Gut microbiota and intestinal FXR mediate the clinical benefits of metformin. Nature medicine 24 (12) (2018)
Cen Xie, Tomoki Yagai, Yuhong Luo, Xianyi Liang, Tao Chen, Qiong Wang, Dongxue Sun, Jie Zhao, Sadeesh K Ramakrishnan, Lulu Sun, Chunmei Jiang, Xiang Xue, Yuan Tian, Kristopher W Krausz, Andrew D Patterson, Yatrik M Shah, Yue Wu, Changtao Jiang, Frank J Gonzalez
Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis. Nature medicine 23 (11) (2017)
Lili Sheng, Prasant Kumar Jena, Hui-Xin Liu, Karen M Kalanetra, Frank J Gonzalez, Samuel W French, Viswanathan V Krishnan, David A Mills, Yu-Jui Yvonne Wan
Gender Differences in Bile Acids and Microbiota in Relationship with Gender Dissimilarity in Steatosis Induced by Diet and FXR Inactivation. Scientific reports 7 (1) (2017)
Avik Roy, Madhuchhanda Kundu, Malabendu Jana, Rama K Mishra, Yeni Yung, Chi-Hao Luan, Frank J Gonzalez, Kalipada Pahan
Identification and characterization of PPARα ligands in the hippocampus. Nature chemical biology 12 (12) (2016)
Mark A G Eldridge, Walter Lerchner, Richard C Saunders, Hiroyuki Kaneko, Kristopher W Krausz, Frank J Gonzalez, Bin Ji, Makoto Higuchi, Takafumi Minamimoto, Barry J Richmond
Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value. Nature neuroscience 19 (1) (2015)
Changtao Jiang, Cen Xie, Ying Lv, Jing Li, Kristopher W Krausz, Jingmin Shi, Chad N Brocker, Dhimant Desai, Shantu G Amin, William H Bisson, Yulan Liu, Oksana Gavrilova, Andrew D Patterson, Frank J Gonzalez
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. Nature communications 6 (2015)

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Publication Activity (10 Years)

Top Topics

Top Venues

Frank J Gonzalez