The Cholangiocarcinoma in the Young (CITY) Study: Tumor Biology, Treatment Patterns, and Survival Outcomes in Adolescent Young Adults With Cholangiocarcinoma.
Leontios PappasIslam BaievStephanie ReyesAndrea Grace BocoboApurva JainKristen SpencerTri Minh LeOsama E RahmaJordan MaurerJen StantonKaren ZhangAnaemy Danner De ArmasThomas T DeleonMarc T RothMary Linton B PetersAndrew X ZhuKylie BoyhenChristine VanCottTushar PatelLewis Rowland RobertsStacie LindseyNora HorickJochen K LennerzA John IafrateLaura Williams GoffKabir ModyMitesh J BoradRachna T ShroffMilind M JavleRobin Kate KelleyLipika GoyalPublished in: JCO precision oncology (2023)
Young patients with CCA had more advanced disease at resection, more commonly received both adjuvant and palliative therapies, and demonstrated improved survival compared with older patients. Given the low clinical trial enrollment and poor outcomes among some AYA cancer populations, data to the contrary in CCA are highly encouraging.