Is pharmacokinetic-guided dosing of desmopressin and von Willebrand factor-containing concentrates in individuals with von Willebrand disease or low von Willebrand factor reliable and feasible? A protocol for a multicentre, non-randomised, open label cohort trial, the OPTI-CLOT: to WiN study.

Jessica M HeijdraWala Al ArashiNico C B de JagerMichael E CloesmeijerLaura H BukkemsChristian M ZwaanFrank W G LeebeekRon A A MathôtMarjon H Cnossennull null

Published in: BMJ open (2022)

NL7212 (NTR7411); Pre-results, EudraCT 2018-001631-46.

Keyphrases

open label
study protocol
clinical trial
phase iii
phase ii
randomized controlled trial
double blind
phase ii study
cross sectional
placebo controlled
radiation therapy
rectal cancer