Dihydrotestosterone Induces Proliferation, Migration, and Invasion of Human Glioblastoma Cell Lines.

Dulce Carolina Rodríguez-LozanoDiana Elisa Velázquez-Vázquez Aylin Del Moral-Morales Ignacio Camacho-Arroyo

Published in: OncoTargets and therapy (2020)

These data suggest that T induces human GBM progression through its conversion into DHT. These results can be related to the chemical structure of DHT, which increases its affinity for AR and decreases five times the rate of dissociation compared to T. Also, it is possible that DHT mediates the effects of T on cell human GBM cells motility by changing the expression of genes involved in tumor infiltration.

Keyphrases

endothelial cells
induced pluripotent stem cells
pluripotent stem cells
poor prognosis
induced apoptosis
signaling pathway
oxidative stress
electronic health record
cell therapy
mass spectrometry
cell cycle arrest
deep learning
cystic fibrosis
pi k akt
electron transfer