DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer.
Varun Sasidharan NairSalman M ToorRowaida Z TahaHibah ShaathEyad ElkordPublished in: Clinical epigenetics (2018)
This study shows that both DNA hypomethylation and H3K9me3 and H3K27me3 repressive histones are involved in upregulation of CTLA-4 and TIGIT genes. However, repressive histones, but not DNA hypomethylation, are involved in upregulation of PD-1 and TIM-3 genes in CRC tumor tissue. These epigenetic modifications could be utilized as diagnostic biomarkers for CRC.
Keyphrases
- dna methylation
- genome wide
- circulating tumor
- bioinformatics analysis
- genome wide identification
- gene expression
- poor prognosis
- endothelial cells
- cell free
- single molecule
- cell proliferation
- signaling pathway
- genome wide analysis
- copy number
- transcription factor
- nucleic acid
- long non coding rna
- pluripotent stem cells