COVID-19 vaccination effectiveness rates by week and sources of bias: a retrospective cohort study.
Anna OstropoletsGeorge HripcsakPublished in: BMJ open (2022)
For vaccine effectiveness studies, observational data need to be scrutinised to ensure compared groups exhibit similar health-seeking behaviour and are equally likely to be captured in the data. While we found that studies may be capable of accurately estimating long-term effectiveness despite bias in early weeks, the early week results should be reported in every study so that we may gain a better understanding of the biases. Given the difference in temporal trends of vaccine exposure and patients' baseline characteristics, indirect comparison of vaccines may produce biased results.
Keyphrases
- randomized controlled trial
- systematic review
- end stage renal disease
- electronic health record
- mental health
- coronavirus disease
- sars cov
- ejection fraction
- newly diagnosed
- healthcare
- chronic kidney disease
- prognostic factors
- clinical trial
- peritoneal dialysis
- drinking water
- data analysis
- cross sectional
- patient reported outcomes
- climate change
- study protocol
- patient reported
- health promotion