An Evaluation of Metabolic, Dietetic, and Nutritional Status Reveals Impaired Nutritional Outcomes in Breast Cancer Patients.
Bruna Ramos da SilvaSarah RufatoMirele S MialichLoris P CruzThais GozzoAlceu A JordaoPublished in: Nutrition and cancer (2022)
Nutritional status can change in breast cancer patients after treatment. However, the metabolic implications of those alterations are poorly understood. We used a cross-sectional study design to compare body composition, lipids, glucose levels, and adiposity indices in breast cancer patients with a matched control and a healthy group. We recruited women who completed their chemotherapy (BC group) and compared them with a group of women without cancer age and body mass index-paired (MC group) and a group of healthy women (HC group). We estimated body composition by bioelectrical impedance analysis, physical function by handgrip strength, and food consumption by 24-hour food record. A blood sample was collected. We calculated visceral obesity indices (VAI and LAP) and insulin resistance-triglyceride glucose (TyG). Eighty-eight women were included (BC = 36, MC = 36, HC = 16). BC patients demonstrated worse phase angle values, nutritional risk index and lower handgrip strength. Additionally, according to the indices, BC had impairments in lipids, worse glucose levels, and elevated visceral fat adiposity and presented important unhealthy dietary patterns characterized by under-recommended protein consumption and higher caloric intake than the other groups. No differences were observed between both control groups. Further investigations are required to examine the underlying mechanisms and the potential longitudinal changes during surveillance.
Keyphrases
- body composition
- insulin resistance
- polycystic ovary syndrome
- resistance training
- adipose tissue
- body mass index
- metabolic syndrome
- bone mineral density
- type diabetes
- high fat diet
- breast cancer risk
- skeletal muscle
- chronic kidney disease
- newly diagnosed
- high fat diet induced
- end stage renal disease
- weight loss
- cervical cancer screening
- radiation therapy
- magnetic resonance imaging
- cross sectional
- pregnant women
- fatty acid
- high resolution
- climate change
- computed tomography
- mass spectrometry
- amino acid
- postmenopausal women
- papillary thyroid