Anti-inflammatory, antioxidant effects, and antimicrobial effect of Bacillus subtilis P223.
Hee-Su JungHye-Won LeeKee-Tae KimNa-Kyoung LeeHyun-Dong PaikPublished in: Food science and biotechnology (2023)
This study aimed to investigate the anti-inflammatory, antioxidant, and antimicrobial effects of Bacillus subtilis P223 which is known to have probiotic properties. B. subtilis P223 that had been killed by heat in LPS-induced RAW 264.7 cells decreased nitric oxide (NO) production. Furthermore, it inhibited the expression of proinflammatory cytokines such interleukin (IL)-1β, IL-6, and tumor necrosis factor-alpha (TNF-α). Heat-killed B. subtilis P223 also inhibited the expression of the nuclear factor (NF)-κB cellular signaling pathway, and it showed reactive oxygen species (ROS) reduction. In DPPH, ABTS, and SOD assay, B. subtilis P223 showed a high antioxidant capacity, and inhibited the growth of skin related pathogens including Staphylococcus aureus and Propionibacterium acnes . This study therefore demonstrated the various functional properties of B. subtilis P223 as probiotics, and suggested the potential for its application as functional material.
Keyphrases
- bacillus subtilis
- anti inflammatory
- lps induced
- staphylococcus aureus
- nuclear factor
- signaling pathway
- reactive oxygen species
- nitric oxide
- oxidative stress
- inflammatory response
- poor prognosis
- induced apoptosis
- rheumatoid arthritis
- toll like receptor
- heat stress
- cell death
- pi k akt
- risk assessment
- cell proliferation
- cystic fibrosis
- nitric oxide synthase
- human health
- climate change
- gram negative
- candida albicans
- amyotrophic lateral sclerosis
- soft tissue