The effect of post-anesthetic administration of dexmedetomidine versus remifentanil on postoperative agitation of strabismus surgery in children: a randomized double-blind clinical trial.
Mohammad Ali SahmeddiniMina JamshidiAshkan PanahMehrdad SalariMahsa BanifatemiFatemeh Kanaani NejadPublished in: Strabismus (2024)
Introduction : Postoperative agitation is a common complication of sevoflurane anesthesia in children and might lead to self-harm and recovery disruption. This study aimed to compare the prophylactic effect of dexmedetomidine and remifentanil on postoperative agitation after anesthesia with sevoflurane. Methods : In this clinical trial, 60 children aged 2 to 7 years with ASA class І, II, candidates for elective strabismus surgery, were randomly assigned to three groups using block randomization. Patients in the first group D received 0.5 µgr/kg dexmedetomidine, the second group R received 0.1 µgr/kg remifentanil, and another group C received normal saline at the end of anesthesia. Children's agitation degree was measured by the Pediatric Anesthesia Emergence Delirium (PAED) scales and the 4-point agitation scale at the time of extubation, entering the recovery room, 10, 20, and 30 minutes after entrance. Data analysis was performed using descriptive and inferential statistical tests. Results : The postoperative agitation and pain were significantly lower among children who received dexmedetomidine compared with those in remifentanil and the control group ( p < .001). It was observed that the administration of dexmedetomidine at the end of anesthesia significantly decreased the incidence of postoperative agitation ( p < .001). None of the patients in group D had a PAED score of over 12. Conclusion : Based on PAED and the 4-point scales, none of the cases in group D had experienced postoperative agitation; this made a significant statistical difference compared with groups C and R ( p -value <. 001). Although both dexmedetomidine and remifentanil can prevent and attenuate postoperative agitation, dexmedetomidine administration seems significantly more effective.
Keyphrases
- patients undergoing
- cardiac surgery
- clinical trial
- end stage renal disease
- young adults
- ejection fraction
- data analysis
- newly diagnosed
- minimally invasive
- chronic kidney disease
- double blind
- acute kidney injury
- prognostic factors
- randomized controlled trial
- cross sectional
- neuropathic pain
- intensive care unit
- spinal cord injury
- percutaneous coronary intervention
- spinal cord
- extracorporeal membrane oxygenation