Polydatin improves osteogenic differentiation of human bone mesenchymal stem cells by stimulating TAZ expression via BMP2-Wnt/β-catenin signaling pathway.
Ying-Shan ShenXiao-Jun ChenSha-Na WuriFan YangFeng-Xiang PangLiang-Liang XuWei HeQiu-Shi WeiPublished in: Stem cell research & therapy (2020)
Taken together, our findings suggest that PD improved the osteogenic differentiation of hBMSCs and maintained the bone matrix in the OVX mouse model through the activation of TAZ, a potential target gene of the BMP2-Wnt/β-catenin pathway.
Keyphrases
- mesenchymal stem cells
- bone regeneration
- mouse model
- bone mineral density
- umbilical cord
- cell proliferation
- stem cells
- endothelial cells
- poor prognosis
- bone marrow
- soft tissue
- bone loss
- cell therapy
- induced pluripotent stem cells
- postmenopausal women
- copy number
- pluripotent stem cells
- risk assessment
- binding protein
- human health
- body composition
- dna methylation
- genome wide analysis