Highly clean recovery of natural antioxidants from lemon peels: Lactic acid-based automatic solvent extraction.

Extraction time was the most effective process factor for the total phenolic and p-coumaric acid yields, while water addition was statistically very important (p < 0.0001) for the naringin and hesperidin yields in the current AMSE system. The second-order models generated for the selected systems represent the data satisfyingly based on the high coefficients of determination (> 0.99), statistically significant p-values (<0.0001), coefficient of variation values (< 10%), and non-significant lack-of-fit values (p > 0.05).