Reno-protective effect of fenofibrate and febuxostat against vancomycin-induced acute renal injury in rats: Targeting PPARγ/NF-κB/COX-II and AMPK/Nrf2/HO-1 signaling pathways.
Ehab A M El-ShouraSouty M Z SharkawiLobna A AbdelzaherBasel A Abdel-WahabYasmine H AhmedAsmaa Ramadan Abdel-SattarPublished in: Immunopharmacology and immunotoxicology (2024)
Our findings show that FX, FENO, and their combination regimen have a nephroprotective impact on VCM-induced kidney injury by suppressing oxidative stress, apoptosis, and the inflammatory response. Renal recovery from VCM-induced injury was accomplished by activation of Nrf2/HO-1 signaling and inhibition of NF-κB expression. This study highlights the importance of FX and FENO as effective therapies for reducing nephrotoxicity in VCM-treated patients.
Keyphrases
- oxidative stress
- diabetic rats
- signaling pathway
- pi k akt
- inflammatory response
- induced apoptosis
- end stage renal disease
- ischemia reperfusion injury
- lps induced
- high glucose
- newly diagnosed
- dna damage
- cell cycle arrest
- drug induced
- poor prognosis
- chronic kidney disease
- ejection fraction
- skeletal muscle
- prognostic factors
- insulin resistance
- lipopolysaccharide induced
- nuclear factor
- endothelial cells
- cancer therapy
- adipose tissue
- type diabetes
- endoplasmic reticulum stress
- epithelial mesenchymal transition
- toll like receptor
- metabolic syndrome
- fatty acid