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CD30 and ALK combination therapy has high therapeutic potency in RANBP2-ALK-rearranged epithelioid inflammatory myofibroblastic sarcoma.

Ashleigh M FordhamJinhan XieAndrew J GiffordCarol WadhamLisa T MorganEmily V A MouldMitali FadiaLei ZhaiHassina MassudiZara S AliGlenn M MarshallRobyn E LukeisJamie I FletcherKaren L MacKenzieToby N Trahair
Published in: British journal of cancer (2020)
CD30 is a therapeutic target in eIMS. BV efficacy is limited by the rapid emergence of resistance. Prolonged survival with combination ALK and CD30-targeted-therapy in the diagnosis model provides the rationale to trial this combination in eIMS patients at diagnosis. This combination could also be considered for other CD30-positive, ALK-rearranged malignancies.
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