Lysosomal membrane permeabilization causes secretion of IL-1β in human vascular smooth muscle cells.

Hiroaki OnoRyo OhtaYuri KawasakiAkira NiwaHidetoshi TakadaTatsutoshi NakahataShouichi OhgaMegumu K Saito

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2018)

These data support a novel role of LMP as a single stimulus for the secretion of IL-1β from hVSMCs, implying the possibility that hVSMCs are an important initiator of the sterile inflammatory response caused by lysosomal disintegration.

Keyphrases

vascular smooth muscle cells
inflammatory response
angiotensin ii
endothelial cells
epstein barr virus
lipopolysaccharide induced
induced pluripotent stem cells
pluripotent stem cells
toll like receptor
data analysis