[Inhibitory effect and mechanism of sodium cantharidate on human tongue squamous cell carcinoma CAL27 cells].

Xin-Ran LiLin ChenJian Meng

Published in: Shanghai kou qiang yi xue = Shanghai journal of stomatology (2024)

SCA can inhibit the proliferation, migration and invasion of human tongue squamous cell carcinoma CAL27 cells. It also down-regulates the ratio of BCL-2/BAX and up-regulates the expression of cleaved caspase 3 protein by regulating the phosphorylation of p53 protein, which induces apoptosis.

Keyphrases

induced apoptosis
squamous cell carcinoma
signaling pathway
endothelial cells
endoplasmic reticulum stress
cell cycle arrest
oxidative stress
cell death
poor prognosis
induced pluripotent stem cells
pluripotent stem cells
lymph node metastasis
pi k akt
long non coding rna
protein kinase