Impaired gut barrier integrity and reduced colonic expression of free fatty acid receptors in patients with Parkinson's disease.
Peng-Hsiang LiaoHsiao-Yen TungWee Shin LimJyh-Shing Roger JangHsun LiChia-Tung ShunHan-Mo ChiuMing-Shiang WuChin-Hsien LinPublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2024)
Colonic expression of ZO-1 and FFAR2 is lower in PD patients compared with unaffected controls, and FFAR2 and FFAR3 levels decline in the pre-motor stage of PD. Our findings implicate a leaky gut phenomenon in PD and reinforce that gut metabolites may contribute to the process of PD.