Evaluating genomic biomarkers associated with resistance or sensitivity to chemotherapy in patients with advanced breast and colorectal cancer.

Jolene GuenterShirin AbadiHoward LimStephen ChiaRyan R WoodsMartin JonesNevena RebicDaniel J RenoufJanessa LaskinMarco Marra

Published in: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (2020)

Among breast cancer patients, higher TYMP expression was associated with sensitivity to capecitabine. Among colorectal cancer patients, higher DICER1 expression was associated with sensitivity to bevacizumab-based therapy. This study supports further assessment of the potential predictive value of mRNA expression of these genomic biomarkers.

Keyphrases

poor prognosis
locally advanced
copy number
metastatic colorectal cancer
binding protein
long non coding rna
squamous cell carcinoma
gene expression
dna methylation
randomized controlled trial
bone marrow
phase ii study
radiation therapy
climate change
rectal cancer
human health
study protocol