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Endo-lysosomal dysfunction in neurodegenerative diseases: opinion on current progress and future direction in the use of exosomes as biomarkers.

Mathieu HermanGrace W RandallJulia L SpiegelDelphina J MaldonadoSabrina Simoes
Published in: Philosophical transactions of the Royal Society of London. Series B, Biological sciences (2024)
Over the past two decades, increased research has highlighted the connection between endosomal trafficking defects and neurodegeneration. The endo-lysosomal network is an important, complex cellular system specialized in the transport of proteins, lipids, and other metabolites, essential for cell homeostasis. Disruption of this pathway is linked to a wide range of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease and frontotemporal dementia. Furthermore, there is strong evidence that defects in this pathway create opportunities for diagnostic and therapeutic intervention. In this Opinion piece, we concisely address the role of endo-lysosomal dysfunction in five neurodegenerative diseases and discuss how future research can investigate this intracellular pathway, including extracellular vesicles with a specific focus on exosomes for the identification of novel disease biomarkers. This article is part of a discussion meeting issue 'Understanding the endo-lysosomal network in neurodegeneration'.
Keyphrases
  • amyotrophic lateral sclerosis
  • randomized controlled trial
  • mesenchymal stem cells
  • stem cells
  • palliative care
  • ms ms
  • current status
  • bone marrow
  • fatty acid
  • mild cognitive impairment
  • network analysis