Transcriptomic Analysis of Hidradenitis Suppurativa: A Unique Molecular Signature with Broad Immune Activation.
Hakim Ben AbdallahAnne BregnhøjLars IversenClaus JohansenPublished in: International journal of molecular sciences (2023)
Hidradenitis suppurativa is a chronic inflammatory skin disease with limited treatment options. The poorly understood pathogenesis hinders the development of effective treatments; therefore, a pressing need exists to further elucidate the molecular mechanisms in hidradenitis suppurativa. This study investigated the underlying inflammatory pathways and cell types in hidradenitis suppurativa using transcriptomic approaches with RNA sequencing of lesional and non-lesional skin biopsies from hidradenitis suppurativa, which was jointly analyzed with previously published transcriptomic data from atopic dermatitis and psoriasis patients. The differential expression and pathway enrichment analyses demonstrated the activation of multiple inflammatory processes, including the innate and adaptive immune systems, implicated in the hidradenitis suppurativa pathogenesis. In agreement, hidradenitis suppurativa exhibited a unique and heterogeneous cell type signature involving lymphoid and myeloid cells such as B cells and macrophages. Furthermore, hidradenitis suppurativa displayed increased expression of T H 1/2/17 signatures with no predominant T H signatures unlike psoriasis (T H 1/17) and atopic dermatitis (T H 2). In summary, our study provides molecular insights into the pathomechanisms in hidradenitis suppurativa, revealing a strong and widespread immune activation, which may benefit from treatment strategies offering a broad immunomodulation of various key inflammatory pathways. Our data not only corroborate previously reported findings but also enhance our understanding of the immune dysregulation in hidradenitis suppurativa, uncovering novel and potential therapeutic targets.
Keyphrases
- ejection fraction
- hidradenitis suppurativa
- atopic dermatitis
- single cell
- oxidative stress
- immune response
- induced apoptosis
- randomized controlled trial
- gene expression
- bone marrow
- dna methylation
- poor prognosis
- big data
- cell proliferation
- risk assessment
- electronic health record
- soft tissue
- acute myeloid leukemia
- mass spectrometry
- systematic review
- machine learning
- end stage renal disease
- newly diagnosed
- binding protein
- ultrasound guided
- peritoneal dialysis
- human health
- patient reported