Clinical outcomes in COVID-19 patients treated with tocilizumab: An individual patient data systematic review.

Daniel Antwi-AmoabengZahara KanjiBrent FordBryce David BeutlerMark S RiddleFaisal Siddiqui

Published in: Journal of medical virology (2020)

Recent data indicate that severe COVID-19 causes a cytokine release storm and is associated with worse clinical outcomes and IL-6 plays an important role. It is suggestive that anti-IL-6 results in the improvement of this hyperinflammatory state. However, to our knowledge, there is no individual patient data systematic review performed to summarize baseline characteristics and clinical outcomes of COVID-19 patients who received tocilizumab.

Keyphrases

systematic review
coronavirus disease
sars cov
electronic health record
meta analyses
rheumatoid arthritis
big data
case report
healthcare
respiratory syndrome coronavirus
rheumatoid arthritis patients
randomized controlled trial
data analysis